Sophora japonica Extract Inhibits Ulcerative Colitis and Colitis-Associated Colon Cancer via Regulation of Lipid Metabolism

Figure 4

Metabolomic analysis of serum in mice with UC and CAC. (a) OPLS-DA was used to analyze the metabolites in serum samples of mice with UC in the CON and DSS groups. (b) and values were used to evaluate the predictive ability of the OPLS-DA model in UC experiments. (c) Volcano plot of differential metabolites between the CON and DSS groups in UC experiments. (d) OPLS-DA was used to analyze the metabolites in serum samples of mice with CAC in the CON and AOM + DSS groups. (e) and values were used to evaluate the predictive ability of the OPLS-DA model in CAC experiments. (f) Volcano plot of differential metabolites between the CON and AOM + DSS groups in CAC experiments. (g) Bubble plots of metabolic pathways enriched by abnormal metabolites in mice with UC. (h) Bubble plots of metabolic pathways enriched by abnormal metabolites in mice with CAC. The vertical axis represents KEGG pathway names, the horizontal axis represents weight values based on topological analysis, and the color of the bubble represents the value. The size of the bubble represents the number of metabolites. Different colors of the subclass are used to distinguish different types of metabolic pathways.