Sophora japonica Extract Inhibits Ulcerative Colitis and Colitis-Associated Colon Cancer via Regulation of Lipid Metabolism

Figure 5

Effects of SJE on metabolic expression profiles in mice with UC and CAC. (a) OPLS-DA analysis of metabolites between the SJE and DSS groups in the UC experiment. (b) OPLS-DA analysis of metabolites between the SJE and AOM + DSS groups in the CAC experiment. (c) STEM analysis was used to screen metabolites that were restored to the CON group in the UC experiment. (d) STEM analysis was used to screen metabolites that were restored to the CON group in the CAC experiment. (e) Classification of common differential metabolites (the vertical axis represents the type of metabolite, and the horizontal axis represents the number of metabolites). (f) Bubble chart showing the enriched pathways modulated by SJE intervention (the vertical axis represents KEGG pathway names, the horizontal axis represents weight values based on topological analysis, the bubble color represents values, and the bubble size represents the number of metabolites; subclass colors are used to distinguish between different metabolic pathway categories). (g) Metabolic pathways influenced by SJE intervention.