Journal of Food Biochemistry

Research Article

Sophora japonica Extract Inhibits Ulcerative Colitis and Colitis-Associated Colon Cancer via Regulation of Lipid Metabolism

Table 1

Endogenous differential metabolites identified in serum.


No	ESI mode	Metabolites	Formula	Molecular weight	RT (min)	m/z	Control vs model trend

1	−	Taurine	C₂H₇NO₃S	125.1470	0.611	124.0081	Down
2^a	−	Uric acid	C₅H₄N₄O₃	168.1103	0.668	167.0208	Down
3	−	L-Histidine	C₆H₉N₃O₂	155.1546	0.695	154.0614	Up
4	−	L-Valine	C₅H₁₁NO₂	117.1463	0.752	116.0724	Up
5	−	L-Tyrosine	C₉H₁₁NO₃	181.1885	1.091	180.0676	Up
6^a	−	Deoxyuridine	C₉H₁₂N₂O₅	228.2020	1.728	227.0682	Up
7	−	Inosine	C₁₀H₁₂N₄O₅	268.2261	1.937	267.0720	Up
8^a	−	Guanosine	C₁₀H₁₃N₅O₅	283.2407	1.956	282.0848	Up
9	−	Pantothenic acid	C₉H₁₇NO₅	219.2350	2.079	218.1030	Up
10^a	−	2-Methylbutanoic acid	C₅H₁₀O₂	102.1317	2.193	101.0605	Up
11^a	−	D-Phenylalanine	C₉H₁₁NO₂	165.1891	2.276	164.0714	Up
12^a	−	Adenine	C₅H₅N₅	135.1267	3.434	134.0472	Down
13^a	−	DL-Tryptophan	C₁₁H₁₂N₂O₂	204.2252	3.461	203.0813	Up
14^a	−	Indoxyl sulfate	C₈H₇NO₄S	213.2100	6.905	212.0023	Up
15^a	−	p-Cresol sulfate	C₇H₈O₄S	188.2010	10.179	187.0054	Up
16	−	Prostaglandin E2	C₂₀H₃₂O₅	352.4651	13.526	351.2175	Down
17^a	−	Prostaglandin D2	C₂₀H₃₂O₅	352.4651	15.841	351.2176	Down
18^a	−	Leukotriene B4	C₂₀H₃₂O₄	336.4657	17.687	335.2230	Down
19^a	−	Taurocholic acid	C₂₆H₄₅NO₇S	515.7030	18.042	514.2848	Down
20^a	−	Deoxycholic acid	C₂₄H₄₀O₄	392.5720	21.103	391.2847	Down
21^a	−	12-Hydroxyeicosatetraenoic acid	C₂₀H₃₂O₃	320.4663	21.300	319.2279	Down
22^a	−	9,12-Octadecadiynoic acid	C₁₈H₂₈O₂	276.4200	22.345	275.2002	Up
23^a	−	7Z,10Z-hexadecadienoic acid	C₁₆H₂₈O₂	252.3923	22.598	251.2001	Up
24^a	−	Myristic acid	C₁₄H₂₈O₂	228.3709	23.066	227.2009	Up
25^a	−	Alpha-linolenic acid	C₁₈H₃₀O₂	278.4296	23.163	277.2157	Up
26^a	−	Methenolone	C₂₀H₃₀O₂	302.4510	23.179	301.2154	Up
27^a	−	Palmitoleic acid	C₁₆H₃₀O₂	254.4082	23.388	253.2165	Up
28^a	−	Pentadecanoic acid	C₁₅H₃₀O₂	242.3975	23.474	241.2171	Down
29	−	Arachidonic acid	C₂₀H₃₂O₂	304.4669	23.744	303.2311	Down
30^a	−	Linoleic acid	C₁₈H₃₂O₂	280.4455	23.784	279.2313	Up
31^a	−	Docosahexaenoic acid	C₂₂H₃₂O₂	328.4883	23.800	327.2308	Up
32^a	−	Docosapentaenoic acid (22n-6)	C₂₂H₃₄O₂	330.5042	24.082	329.2491	Up
33^a	−	Palmitic acid	C₁₆H₃₂O₂	256.4241	24.122	255.2319	Up
34^a	−	Adrenic acid	C₂₂H₃₆O₂	332.5200	24.703	331.2628	Up
35	−	Stearic acid	C₁₈H₃₆O₂	284.4772	25.364	283.2653	Up
36^a	+	5-amino valeric acid betaine	C₈H₁₇NO₂	159.2290	0.702	160.1326	Up
37^a	+	3′-AMP	C₁₀H₁₄N₅O₇P	347.2212	0.868	348.0692	Down
38	+	L-Methionine	C₅H₁₁NO₂S	149.2110	0.928	150.0578	Up
39^a	+	Adenosine	C₁₀H₁₃N₅O₄	267.2413	1.178	268.1013	Up
40^a	+	Xanthine	C₅H₄N₄O₂	152.1109	1.285	153.0396	Up
41	+	Hypoxanthine	C₅H₄N₄O	136.1115	1.961	137.0463	Up
42	+	L-Phenylalanine	C₉H₁₁NO₂	165.1891	2.531	166.0859	Up
43^a	+	Pyrogallol-2-O-glucuronide	C₁₂H₁₄O₉	302.2342	2.741	325.0526	Up
44^a	+	Butyrylcarnitine	C₁₁H₂₁NO₄	231.2920	2.797	232.1516	Down
45^a	+	L-Tryptophan	C₁₁H₁₂N₂O₂	204.2252	4.113	205.0967	Up
46^a	+	Corticosterone	C₂₁H₃₀O₄	346.4605	11.253	347.2198	Up
47^a	+	Beta-muricholic acid	C₂₄H₄₀O₅	408.5790	13.952	431.2745	Down
48^a	+	Tetradecanoylcarnitine	C₂₁H₄₂NO₄	372.5690	14.918	372.3095	Up
49	+	Cholic acid	C₂₄H₄₀O₅	408.5714	15.498	431.2745	Down
50^a	+	2,2,4-Trimethyl-1,3-pentadienol diisobutyrate	C₁₆H₃₀O₄	286.4070	16.391	309.2026	Up
51^a	+	Oleoylcarnitine	C₂₅H₄₈NO₄	426.6610	16.407	426.3555	Down
52^a	+	Eicosapentaenoic acid	C₂₀H₃₀O₂	302.4510	16.857	303.2297	Up
53^a	+	LysoPC (20 : 5(5Z,8Z,11Z,14Z,17Z)/0 : 0)	C₂₈H₄₈NO₇P	541.6570	17.747	542.3217	Up
54^a	+	LysoPC (18 : 2(9Z,12Z)/0 : 0)	C₂₆H₅₀NO₇P	519.6515	17.767	520.3379	Down
55^a	+	LysoPC (16 : 0)	C₂₄H₅₀NO₇P	495.6301	18.443	496.3388	Down
56^a	+	LysoPC (18 : 1(9Z)/0 : 0)	C₂₆H₅₂NO₇P	521.6673	18.996	544.3343	Down
57^a	+	LysoPC (18 : 0)	C₂₆H₅₄NO₇P	523.6832	21.275	524.3693	Down

Metabolites were matched by standards; ^ametabolites were confirmed by MS/MS fragmentation.