Caffeic Acid Dimethyl Ether Ameliorates Excessive Glucose and Lipid-Induced Insulin Secretion Dysfunction in Pancreatic Beta-Cells through the miR-378b–PI3K–AKT Pathway

Figure 1

Effects of CADE on impaired insulin secretion in mice. (a) The experimental schedule. (b) Body weight. (c) Blood glucose level after 8 h of fasting. (d) OGTT and area under the curve during OGTT. (e) H&E staining of mouse pancreatic tissue (scale bar: 50 μm). (f) Immunofluorescence of insulin in mouse pancreatic islets (scale bar: 50 μm) and quantification. (g) Insulin secretion levels. (h) miR-378b levels in the pancreas. The results are presented as the mean ± SD from three experiments. STZ, streptozotocin; i.p., intraperitoneal injection; i.g., intragastric administration; FBG, fasting blood glucose; and OGTT, oral glucose tolerance test. ^#, ^## vs. the NC group; , vs. the DC group.

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