Caffeic Acid Dimethyl Ether Ameliorates Excessive Glucose and Lipid-Induced Insulin Secretion Dysfunction in Pancreatic Beta-Cells through the miR-378b–PI3K–AKT Pathway

<div>Effects of CADE on HG + HF-induced impairment of insulin secretion in 1.1B4 cells. (a) Effects of CADE on cell viability in 1.1B4 cells. (b) Effects of glucose and sodium palmitate on cell viability in 1.1B4 cells. (c) Effects of CADE on cell viability in glucose and sodium palmitate-induced 1.1B4 cells. (d) Immunofluorescence analysis of insulin (scale bar: 100 <i>μ</i>m) and quantification. (e) Pseudo-islet masses (scale bar: 100 <i>μ</i>m). (f) Insulin secretion levels of pseudo-islet masses. (g) Proinsulin mRNA levels. (h) Expression levels of miR-378b in 1.1B4 cells. The results are presented as the mean ± SD from three experiments. PA: sodium palmitate. <sup>#</sup><span class="nowrap"><svg height="9.2729pt" id="M6" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 47.0146 9.2729" width="47.0146pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.096,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 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555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the HG + HF group.</div>

Journal of Food Biochemistry

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Figure 2

Figure 2: Caffeic Acid Dimethyl Ether Ameliorates Excessive Glucose and Lipid-Induced Insulin Secretion Dysfunction in Pancreatic Beta-Cells through the miR-378b–PI3K–AKT Pathway 

Figure 2 | Caffeic Acid Dimethyl Ether Ameliorates Excessive Glucose and Lipid-Induced Insulin Secretion Dysfunction in Pancreatic Beta-Cells through the miR-378b–PI3K–AKT Pathway 