Capsaicin Enhances Temozolomide-Resistant Glioblastoma Cells’ Chemosensitivity and Ferroptosis through FHOD1/IRF2 Downregulation

<div>Capsaicin treatment showed antiproliferation effects in TMZ-resistant and TMZ-free GBM cells: (a) CCK-8 results in U87, U251, U87-R, and U251-R cells treated with TMZ, (b) CCK-8 results in U87-R and U251-R cells treated with TMZ and capsaicin, and (c) BrdU incorporation in U87-R and U251-R cells treated with TMZ and capsaicin. <span class="nowrap"><svg height="10.7395pt" id="M7" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 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Journal of Food Biochemistry

fig1

Figure 1

Figure 1: Capsaicin Enhances Temozolomide-Resistant Glioblastoma Cells’ Chemosensitivity and Ferroptosis through FHOD1/IRF2 Downregulation 