Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR-ERK Signaling Pathway

Figure 1

Active components in licorice. (a) The 2D structure. (b) The ADMET property. (c) The toxicity prediction. Oral bioavailability (OB) exceeding 30% reduces the amount of an administered drug necessary to achieve a desired pharmacological effect and, therefore, could reduce the risk of side-effects and toxicity. Drug-likeness (DL) exceeding 0.18 was considered as having good drug-likeness. LD50: lethal dose 50%. Toxicity class I: fatal if swallowed (LD50 ≤ 5 mg/kg); toxicity class II: fatal if swallowed (5 < LD50 ≤ 50 mg/kg); toxicity class III: toxic if swallowed (50 mg/kg < LD50 ≤ 300 mg/kg); toxicity class IV: harmful if swallowed (300 mg/kg < LD50 ≤ 2000 mg/kg); toxicity class V: may be harmful if swallowed (2000 mg/kg < LD50 ≤ 5000 mg/kg); toxicity class VI: nontoxic (LD50 > 5000 mg/kg). (d) The IC50 of active components in licorice. IC50: half-maximal inhibitory concentration. indicates differences between two groups; was considered to be a significant difference; was considered to be a highly significant difference.

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