Quercetin Promotes Apoptosis of Gastric Cancer Cells through the EGFR-ERK Signaling Pathway

Figure 4

Network pharmacology and the molecular docking. (a) The gastric cancer-related targets. (b) Venn diagram of the targets in licorice and gastric cancer. (c) The PPI network. (d) KEGG enrichment analysis. (e) The map of the ERK signal pathway (this image was from the KEGG database and the purple box is “EGFR-ERK signaling pathway). (f) Molecular docking (the molecular docking results are from Schrodinger 2020-4 software and a docking score of ≤ −5 for a compound indicated its potential activity). (g) The RMSD fluctuations over time of the “EGFR-quercetin” complex system. (h) The RMSF of each residue of the “EGFR-quercetin” complex system during the molecular dynamics (last 10 ns). (i) The binding energy of the top ten residues that contribute most to ligand binding in the “EGFR-quercetin” complex system. RMSD, root mean square deviation and RMSF, root mean square fluctuation.

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