Salidroside Alleviates Myocardial Ischemia Reperfusion by Balancing Mitochondrial Homeostasis via Nrf2

Figure 7

Inhibition of Nrf2 prevents the protective effect of SAL on mitochondrial function against H/R injury in H9c2. (a) Western blotting was used to measure the expression of COX IV, VDAC1, and TOMM20 after H/R injury. (b) PCR was used to analyze the transcription of Drp1, Fis1, OPA1, Mfn1, and Mfn2 after H/R injury. (c) Western blotting was used to measure the expression of AMPK, PGC-1α, and PPARα after H/R injury. Values are presented as mean ± SEM. , , and versus the control group; and versus the H/R group; , , and versus the SAL group; , , and versus the ML group.

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