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Journal of Healthcare Engineering
Volume 1 (2010), Issue 3, Pages 477-508
Research Article

In Vivo Diffuse Optical Tomography and Fluorescence Molecular Tomography

Mingze Li, Yonghong Zhang, and Jing Bai

Tsinghua University, Department of Biomedical Engineering, School of Medicine, Beijing 100084, China

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diffuse optical tomography (DOT) and fluorescence molecular tomography (FMT) are two attractive imaging techniques for in vivo physiological and psychological research. They have distinct advantages such as non-invasiveness, non-ionizing radiation, high sensitivity and longitudinal monitoring. This paper reviews the key components of DOT and FMT. Light propagation model, mathematical reconstruction algorithm, imaging instrumentation and medical applications are included. Future challenges and perspective on optical tomography are discussed.