Modelling of Thermal Hyperemia in the Skin of Type 2 Diabetic Patients

Bandini, Andrea; Orlandi, Silvia; Manfredi, Claudia; Evangelisti, Attilio; Barrella, Massimo; Bevilacqua, Maurizio; Bocchi, Leonardo

doi:https://doi.org/10.1260/2040-2295.4.4.541

Journal of Healthcare Engineering

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Research Article | Open Access

Volume 4 | Article ID 729867 | https://doi.org/10.1260/2040-2295.4.4.541

Modelling of Thermal Hyperemia in the Skin of Type 2 Diabetic Patients

Andrea Bandini,¹Silvia Orlandi,¹Claudia Manfredi,¹Attilio Evangelisti,¹Massimo Barrella,²Maurizio Bevilacqua,³and Leonardo Bocchi¹

Received01 Mar 2013

Accepted01 Aug 2013

Abstract

The microcirculatory response to thermal stimulation involves both an axon reflex and NO-mediated activation. The analysis of the microcirculatory flow following thermal stimulation may therefore enhance the detection of any impairment of the small unmyelinated fibres that are involved in the axon reflex. The aim of this work is to establish a method of non-invasive measurement of small fibre impairment. The microcirculatory flow in response to local heating is measured by using a laser Doppler instrument, and mathematically modelled to extract a set of quantitative parameters. The results confirm that there is a significant difference in the parameters modelling the axon reflex between diabetic and control subjects, while no significant difference is found in the parameters modelling the NO-mediated activation.

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Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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