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Journal of Healthcare Engineering
Volume 4, Issue 4, Pages 529-540
http://dx.doi.org/10.1260/2040-2295.4.4.529
Research Article

Evaluation of Postprandial Glucose Excursion Using a Novel Minimally Invasive Glucose Area-Under-the-Curve Monitoring System

Sachi Kuranuki,1 Toshiyuki Sato,2 Seiki Okada,2 Samiko Hosoya,2 Akinobu Seko,3 Kaya Sugihara,3 and Teiji Nakamura1

1Faculty of Health & Social Work, Kanagawa University of Human Services, Kanagawa, Japan
2Central Research Laboratories, Japan
3New Business Development Group, Sysmex Corporation, Kobe, Japan

Received 1 March 2013; Accepted 1 August 2013

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: To develop a minimally invasive interstitial fluid extraction technology (MIET) to monitor postprandial glucose area under the curve (AUC) without blood sampling, we evaluated the accuracy of glucose AUC measured by MIET and compared with that by blood sampling after food intake. Methods: Interstitial fluid glucose AUC (IG-AUC) following consumption of 6 different types of foods was measured by MIET. MIET consisted of stamping microneedle arrays, placing hydrogel patches on the areas, and calculating IG-AUC based on glucose levels in the hydrogels. Glycemic index (GI) was determined using IG-AUC and reference AUC measured by blood sampling. Results: IG-AUC strongly correlated with reference AUC (R = 0.91), and GI determined using IG-AUC showed good correlation with that determined by reference AUC (R = 0.88). Conclusions: IG-AUC obtained by MIET can accurately predict the postprandial glucose excursion without blood sampling. In addition, feasibility of GI measurement by MIET was confirmed.