The Impact of Diagnostic Code Misclassification on Optimizing the Experimental Design of Genetic Association Studies

Figure 1

Statistical power versus ICD code instances, baseline model. From the mathematical model specified, power was calculated using the set of parameters from the baseline model. The results show the trade-off between the sample size, misclassification rates, and statistical power to detect genetic association. For the baseline model, the peak of power occurs when the number of instances is 7.