Automated Diagnosis of Hepatitis B Using Multilayer Mamdani Fuzzy Inference System

Table 2

Layer II input variables of the proposed ADHB-ML-MFIS expert system [13].

Sr no.	Input parameters	Ranges	Semantic sign	Reference range/cutoff value
1	HBsAg	LT < 0.9	Negative	1.0
		B/W 0.9–1.0	Borderline
		GT > 1.0	Positive
2	Anti-HBsAg	2–10 IU/L	Negative	10 IU/L
		GT > 10	Positive
3	Anti-HBcAg	LT < 1.0	Positive	1.0
		B/W 0.9–1.1	Borderline
		GT > 1.0	Negative
4	Anti-HBcAg-IgM	LT < 1.0	Negative	1.0
		B/W 0.9–1.1	Borderline
		GT > 1.0	Positive
5	HBeAg	LT < 0.67	Negative	0.67
		GT > 0.67	Positive
6	Anti-HBeAg	LT < 0.75	Positive	0.75
		GT > 0.75	Negative
7	HBV-DNA	LT < 10	Negative	10 IU/L
		GT > 10	Positive

LT = less than; GT = greater than; B/W = between; IU/L = international unit per liter; anti-HBsAg = HBsAb; anti-HBcAg-IgM = HBcAb-IgM; anti-HBcAg = HBcAb; anti-HBeAg = anti-HBeAg.