Wnt/β-Catenin, Carbohydrate Metabolism, and PI3K-Akt Signaling Pathway-Related Genes as Potential Cancer Predictors

Table 4

Performances of pathway-related genes and DEGs in test sets.

Genes	Test set
	COAD (%) (normal/tumor = 9/123)				BRCA (%) (normal/tumor = 35/332)				STAD (%) (normal/tumor = 11/112)				PRAD (%) (normal/tumor = 16/149)
	SVM	RF	DT	KNN	SVM	RF	DT	KNN	SVM	RF	DT	KNN	SVM	RF	DT	KNN
Wnt	100.00	99.90	94.03	99.86	99.95	97.64	88.79	100.00	99.26	98.70	79.13	99.75	95.76	95.55	76.65	95.26
Ca-Me	100.00	100.00	99.18	100.00	99.96	99.50	88.42	100.00	99.10	97.88	75.04	97.44	94.75	96.95	79.67	95.11
PI3K	100.00	100.00	100.00	99.95	99.92	99.43	98.41	99.66	99.35	98.53	84.57	97.44	96.56	91.61	86.01	95.91
TLR	100.00	97.01	88.48	100.00	99.87	99.35	90.17	99.44	98.62	98.01	86.36	95.37	93.20	92.05	78.56	86.79
TH	100.00	99.72	99.18	99.86	99.93	98.86	83.38	99.57	99.43	98.45	80.92	97.93	96.60	89.53	64.91	91.42
RPSC	100.00	99.86	94.03	99.95	99.93	99.93	94.13	99.84	99.26	98.25	83.68	98.74	94.67	93.12	79.88	95.05
DEGs	100.00	100.00	100.00	100.00	100.00	99.96	99.03	99.29	99.35	99.10	88.67	96.02	93.37	92.76	85.48	91.23

Note. COAD, colorectal cancer; BRCA, breast cancer; STAD, gastric cancer; PRAD, prostate cancer; Wnt, Wnt signaling pathway; Ca-Me, carbohydrate metabolism signaling pathway; PI3K, PI3K-Akt signaling pathway; TLR, toll-like receptor signaling pathway; TH, thyroid hormone signaling pathway; RPSC, signaling pathways regulating pluripotency of stem cells.