Smoking Is a Risk Factor of Coronary Heart Disease through HDL-C in Chinese T2DM Patients: A Mediation Analysis
Table 3
Odds ratio (95% confidence interval, CI) of stroke for smoking in participants.
N (%)
Model A
Model B
Model C
OR (95% CI)
OR (95% CI)
OR (95% CI)
Smoking
None (reference)
18 (12.9)
1
1
1
Yes
21 (15.1)
1.20 (0.61–2.36)
1.15 (0.55–2.53)
1.25 (0.57–2.74)
0.605
0.673
0.573
CPD
None (reference)
18 (12.9)
1
1
1
≤20 (day)
14 (13.2)
1.02 (0.48–2.16)
0.90 (0.38–2.09)
0.94 (0.40–2.25)
>20 (day)
7 (21.2)
1.81 (0.69–4.78)
2.68 (0.87–8.28)
2.76 (0.89–8.53)
for trend
0.333
0.228
0.186
Time of smoking
None (reference)
18 (12.9)
1
1
1
≤20 years
10 (14.3)
1.16 (0.50–2.66)
1.88 (0.71–4.98)
1.91 (0.70–5.21)
>20 years
11 (16.9)
1.42 (0.63–3.20)
0.92 (0.37–2.30)
1.01 (0.39–2.56)
for trend
0.406
0.999
0.856
Cumulative smoking
None (reference)
18 (12.9)
1
1
1
≤20 pack-years
7 (9.3)
0.69 (0.28–1.74)
0.75 (0.27–2.07)
0.77 (0.27–2.21)
>20 pack-years
14 (21.9)
1.88 (0.87–4.07)
1.66 (0.69–3.98)
1.79 (0.73–4.39)
for trend
0.167
0.314
0.255
Variables are included as continuous variables
None (reference)
1
1
1
CPD
1.02 (0.99–1.04)
1.02 (1.00–1.05)
1.02 (1.00–1.05)
0.18
0.09
0.051
None (reference)
1
1
1
Smoking time (years)
1.01 (0.99–1.03)
1.00 (0.97–1.02)
1.00 (0.97–1.02)
0.421
0.678
0.885
None (reference)
1
1
1
Cumulative smoking (pack-years)
1.01 (1.00–1.03)
1.01 (0.99–1.03)
1.01 (0.99–1.03)
0.083
0.385
0.336
Model A: crude model; Model B: adjusted for age, gender, origin, and occupation; Model C: adjusted for age, gender, origin, occupation, drinking, BMI, WC, and diabetes duration; and CPD: cigarettes per day.
