Journal of Healthcare Engineering

Research Article

[Retracted] Comprehensive Analysis of Regulatory Network for LINC00472 in Clear Cell Renal Cell Carcinoma

Table 2

Significantly enriched GO BP and KEGG Pathway analysis results in the two modules.


Module		Description	P. adjust	Counts

Module 1	GO BP terms	Immune response	1.08947E − 17	24
		Interferon-gamma-mediated signaling pathway	3.01473E − 15	21
		Inflammatory response	1.71115E − 12	10
		Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.80454E − 10	8
		Antigen processing and presentation	2.03552E − 10	12
		Type I interferon signaling pathway	1.77292E − 08	8
	KEGG Pathway	Staphylococcus aureus infection	1.0228E − 20	14
		Viral myocarditis	5.11466E − 15	14
		Allograft rejection	6.1499E − 14	13
		Graft-versus-host disease	1.54791E − 13	13
		Antigen processing and presentation	2.32687E − 13	15
		Phagosome	5.89325E − 12	14
		Type I diabetes mellitus	1.08722E − 11	13
		Autoimmune thyroid disease	2.98279E − 11	13

Module 2	GO BP terms	Angiogenesis	7.80442E − 13	7
		Extracellular matrix organization	6.35682E − 12	16
		Response to hypoxia	1.17332E − 11	5
		Type I interferon signaling pathway	1.77292E − 08	6
		Platelet degranulation	2.34138E − 08	14
		Collagen catabolic process	1.60661E − 07	11
		Defense response to virus	1.66166E − 07	5
	KEGG Pathway	Focal adhesion	1.64514E − 07	13
	KEGG Pathway	ECM-receptor interaction	3.56477E − 06	12

Immune response: CXCL10, B2M, APLN, C5AR1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DPA1, GBP2, HLA-DRA, HLA-DQB1, GPR183, HLA-DRB1, C3; interferon-gamma-mediated signaling pathway: HLA-DQB1, ICAM1, HLA-DRB1, HLA-A, IFI30, HLA-C, OAS1, HLA-B, OAS2, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, B2M, CD44, HLA-DRB5, HLA-DPA1, HLA-DPB1, GBP2, GBP1, HLA-DRA, CXCL9, OAS1, OAS2; inflammatory response: C3AR1, C3, FPR1, CXCL9, FPR3, CXCL10, CCL20, CXCR4, C5AR1, ANXA1; antigen processing and presentation of peptide or polysaccharide antigen via MHC class II: HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-DQA1, HLA-DRA; antigen processing and presentation: HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; type I interferon signaling pathway: HLA-A, HLA-C, OAS1, HLA-B, OAS2, HLA-E, HLA-F, GBP2; Staphylococcus aureus infection: HLA-DQB1, C3AR1, HLA-DRB1, C3, FPR1, FPR3, HLA-DRB5, HLA-DPB1, ICAM1, C5AR1, HLA-DQA2, HLA-DQA1, HLA-DPA1, HLA-DRA; viral myocarditis: HLA-DQB1, ICAM1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; allograft rejection: HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; graft-versus-host disease: HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; antigen processing and presentation: HLA-DQB1, HLA-DRB1, HLA-A, IFI30, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, B2M, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; phagosome: HLA-DQB1, HLA-DRB1, C3, HLA-DRB5, HLA-DPB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DPA1, HLA-DRA; type I diabetes mellitus: HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; autoimmune thyroid disease: HLA-DQB1, HLA-DRB1, HLA-A, HLA-C, HLA-B, HLA-E, HLA-DQA2, HLA-DQA1, HLA-F, HLA-DRB5, HLA-DPA1, HLA-DPB1, HLA-DRA; angiogenesis: SERPINE1, COL8A1, FN1, COL4A2, COL15A1, VEGFB, VEGFA; extracellular matrix organization: ITGB2, COL6A3, SERPINE1, COL6A2, COL6A1, COL8A1, FN1, COL4A2, COL4A1, SPARC, COL5A2, COL5A1, VWF, COL1A2, VCAN, COL1A1; Response to hypoxia: TGFB1, PLOD1, PLOD2, VEGFB, VEGFA; type I interferon signaling pathway: BST2, SAMHD1, PSMB8, STAT2, ISG20, ISG15; platelet degranulation: ALDOA, CLU, SERPING1, SPARC, TGFB1, TIMP1, VEGFB, VWF, CD36, SERPINE1, VEGFA, SERPINA1, CFD, FN1; collagen catabolic process: COL4A2, COL4A1, COL6A3, COL1A2, COL6A2, COL15A1, COL6A1, COL1A1, COL8A1, COL5A2, COL5A1; defense response to virus: BST2, SAMHD1, STAT2, ISG20, ISG15; focal adhesion: COL6A3, COL6A2, COL6A1, FN1, COL4A2, COL4A1, COL5A2, COL5A1, VEGFB, VWF, VEGFA, COL1A2, COL1A1; ECM-receptor interaction: VWF, COL4A2, COL4A1, CD36, COL6A3, COL1A2, COL6A2, COL6A1, COL1A1, COL5A2, COL5A1, FN1.