[Retracted] Identification of ZEB2 as an Immune-Associated Gene in Endometrial Carcinoma and Associated with Macrophage Infiltration by Bioinformatic Analysis

Figure 3

Downregulation of ZEB2 and association with tumor infiltration. Significant downexpression of ZEB2 mRNA level in EC compared with normal tissues in two datasets: E-MTAB-7039 (a) and GSE17025 (b). Significant associations of ZEB2 expression (normalized counts) with tumor purity (c), estimate score (d), stromal score (e), and immune score (f) in TCGA-UCEC dataset calculated by ESTIMATE package in R statistic software (). (g) Association of ZEB2 expression (log₂TPM) with tumor purity validated all 6 types of immune cells (B cell, CD8⁺/T cell, CD4⁺/T cell, macrophage, neutrophil, and dendritic cell) in TCGA-UCEC using TIMER2.0 (https://timer.cistrome.org/) website. EC, endometrial carcinoma; ESTIMATE, estimation of stromal and immune cells in malignant tumors using expression data; TIMER, tumor immune estimation resource; TPM, transcripts per million; UCEC, uterine corpus endometrial carcinoma; UMAP, Uniform Manifold Approximation and Projection. value <0.05 or <0.01.

(a)

(b)

(c)

(d)

(e)

(f)

(g)