Research Article

[Retracted] The Function and Prognostic Value of RNA-Binding Proteins in Colorectal Adenocarcinoma Were Analyzed Based on Bioinformatics of Smart Medical Big Data

Table 1

GO and KEGG enrichment analysis of differently expressed RBPs.

GO term value

Down regulated RBPs
 Biological processes (BP)Regulation of translation3.22E−07
Regulation of cellular amide metabolic process9.25E−07
Regulation of mRNA metabolic processing3.42E−07
Regulation of mRNA processing1.30E−07
Negative regulation of translation2.26E−06
Regulation of RNA splicing2.48E−06
Defense response to virus1.37E−09
Response to virus2.55E−08

 Cellular component (CC)Endolysosome membrane7.73E−06
Endolysosome2.39E−05
Cytoplasmic ribonucleoprotein granule0.000335342
Ribonucleoprotein granule0.000422761

 Molecular function (MF)mRNA 3′-UTR binding4.75E−13
mRNA 3′-UTR AU-rich region binding2.24E−12
AU-rich element binding4.02E−12
Double-stranded RNA-binding1.52E−10
Transition regulator activity4.76E−07

 KEGG pathwayProgesterone-mediated oocyte maturation0.00145067
Toll-like receptor signalling pathway0.00167211
Oocyte meiosis0.00302753

Up regulated RBPs
 Biological processes (BP)ncRNA metabolic process6.50E−28
ncRNA processing2.15E−24
Nucleic acid phosphodiester bond hydrolysis1.50E−15
Ribonucleoprotein complex biogenesis3.07E−13
RNA phosphodiester bond hydrolysis7.97E−19
RNA localization3.61E−13
Ribosome biogenesis8.39E−15

 Cellular component (CC)Cytoplasmic ribonucleoprotein granule3.33E−06
Ribonucleoprotein granule5.90E−09
Preribosome2.66E−07
P granule4.62E−06

 Molecular function (MF)Catalytic activity, acting on RNA3.54E−26
Nuclease activity4.55E−14
Ribonuclease activity4.55E−14
mRNA 3′-UTR binding4.82E−10
Catalytic activity, acting on tRNA8.69E−09

 KEGG pathwayRibosome biogenesis in eukaryotes8.34E−11
RNA transport5.55E−10
mRNA surveillance pathway1.00E−08
RNA degradation3.86E−05