Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway

Figure 1

Tunicamycin induces apoptosis in MDA-MB-231 cells and its Wnt/β-catenin pathway in a dose-dependent manner. Different doses of tunicamycin were used to treat the MDA-MB-231 cells. (a–c) Western blotting shows the level of GRP78, CHOP, β-catenin, phospho-β-catenin, and apoptosis proteins, Bcl-2 and Bax. Three independent experiments were performed. (d) Cell viability was measured by an MTT assay. Six independent experiments were performed. Values shown (n = 3 or 6) are the mean ± SD, or compared with 0 group.

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