Review Article

Deep Learning in the Detection and Diagnosis of COVID-19 Using Radiology Modalities: A Systematic Review

Table 1

Studies evaluating deep learning algorithms used for COVID-19 detection and diagnosis.

Reference (country)Aim of the studyPopulationFeature engineeringML methodModelType of dataValidation results

Saiz and Barandiaran, [62] (Spain)Detection1500Automatic feature extractionCNN with transfer learningVGG-16 SDDX-rayAccuracy: 94.92%, sensitivity: 94.92%, specificity: 92%
Ni et al., [34] (China)Detection14531Prominent features selectedDeep learningConvolutional MVP-Net and 3D U-NetCT imagesF1 score: 97% in detecting lesions, sensitivity: 100%, for detecting patient sensitivity for per-lung Lobe lesion: 0.96%
Wang et al., [21] (China)Diagnosis and prognosis5372 (two datasets)Not used for diagnosisDeep learningDenseNet121-FPNCT imagesAUC = 87% and 88%, sensitivity: 80.3% and 79.35%, specificity: 76.3% and 81.1%
Rahimzadeh & Attar, [50] (Iran)Diagnosis11302 images (open source)Automatic feature extractionDeep learningXception and ResNet50V2X-rayAccuracy: 95.5%, overall average accuracy: 91.4%
Panwar et al., [36] (India)Fast detection337 images (open source)Not usedDeep learning (nCOVnet)VGG-16X-raySensitivity: 97.62%, specificity: 78.57%, accuracy: 88.10%
Ardakani et al., [30] (Iran)Detection194Not usedDeep learningAlexNet, VGG-16, VGG-19, SqueezeNet, GoogLeNet, etc.CT imagesSensitivity: 100%, specificity: 99.02%, accuracy: 99.51%
Li et al., [46] (China)Diagnosis4356 CT exams from 3322 patientsAutomatic feature extractionDeep learningResNet-50 as backbone of main modelCT imagesSensitivity: 90%, specificity: 96%
Li et al., [19] (Greece)Automatic diagnosis2914Automatic feature extractionCNN with transfer learningMobileNetV2X-rayAccuracy: 96.78%, sensitivity: 98.66%, specificity: 96.46%
Sethy et al., [51] (India)Diagnosis381Automatic feature extractionCNN and SVMResNet-50X-raySensitivity: 95.33%
Song et al., [37] (Chain and USA)Detection227Automatic feature extractionDeep learning (CoroNet)BigBiGAN1CT imagesSensitivity: 85%, specificity: 88%
Brunese et al., [31] (Italy)Detection6,523Automatic feature extractionDeep learning (CoroNet)VGG-16X-rayAccuracy: 97%
Butt et al., [42] (USA)Classification (diagnosis)618Automatic feature extractionCNNResNet-18CT imagesSensitivity: 98.2%, specificity: 92.2%
Loey and et al., [63] (Egypt)Diagnosis (classification)306Automatic feature extractionDeep learningGoogLeNetX-rayAccuracy: 100%
Ozturk et al., [35] (Turkey)Automated detection2 databasesAutomatic feature extractionDeep learningDarkNetX-rayBinary case accuracy: 98.08%, multiclass cases accuracy: 87.02%
El Asnaoui and Chawki, [58] (Morocco)Diagnosis6087AutomaticDeep learningInception_ResNet_V2X-ray and CTInception_ResNet_V2 accuracy: 92.18%, DenseNet201 accuracy: 88.09%
Yang et al., [59] (China)Detection295AutomaticDeep learningDenseNetCT imagesAccuracy: 92%, sensitivities: 97%, specificity: 0.87
Jaiswal et al., [33] (India)Detection2492 (open source)AutomaticDeep transfer learningDenseNet201CT imagesPrecision: 96.29%, specificity: 96.21%, accuracy: 96.25%
Mahmud et al., [61] (Bangladesh)Diagnosis5856Not mentionedDeep learning (CNN)CovXNetX-rayAccuracy of multiple classes: 90.2%
Singh et al., [52] (India)Classification (diagnosis)Not mentionedAutomatics using CNNCNN, ANN, and ANFISNot mentionedCT imagesProposed model is compared with CNN, ANFIS, and ANN models and it shows high performance
Ko et al., [45] (Korea)Diagnosis (differentiate)3993 patientsAutomatic feature extractionDeep learning (FCONet)ResNet-50CT imagesSensitivity: 99.58%, specificity: 100.00%, accuracy: 99.87%
Wu et al., [56] (China)Screening (diagnosis)495Automatic feature extractionDeep learning (CoroNet)VGG-19CT imagesAccuracy: 76.0%, sensitivity: 81.1%, specificity: 61.15%
Vaid et al., [38] (Canada)Detection181Automatic feature extractionDeep learning (CoroNet)VGG-19X-rayAccuracy: 96.3%
Ucar & Korkmaz, [54] (Turkey)Classification (diagnosis)PublicAutomatic feature extractionCNNDeep Bayes SqueezeNetX-rayAccuracy for overall class: 98.3%
Toğaçar et al, [53] (Turkey)DiagnosisTwo open sources (n = 295)Automatic feature extractionDeep learning (CoroNet)SqueezeNet and MobileNetX-rayClassification rate: 99.27%
Khan et al., [57] (India)Detection and diagnosisTwo datasets (n = 1300)Automatic feature extractionDeep learning (CoroNet)XceptionX-rayAccuracy: 89.6%
Wu et al., [56] (China)Screening (diagnosis)495Automatic feature extractionDeep learning (CNN)ResNet-50CT imagesAccuracy: 0.819%, sensitivity: 0.760%, specificity: 0.811%
Yi et al., [40] (USA)Classification (detection)88Automatic feature extractionDeep learning (CNN)Not mentionedX-raySensitivity: 89%
Martínez et al., [64] (Columbia)Detection240Automatic feature extractionCNNNASNet2X-rayAccuracy: 97%
Das et al., [43] (India)Screening (diagnosis)6845Automatic feature extractionDeep learning (CNN)Truncated inception netX-raySensitivity: 88%, specificity: 100%
Hasan et al., [44] (Iraq)Diagnosis (classification)321Q-deformed entropy feature extractionDeep transfer learningLSTM neural network classifierCT imagesAccuracy: 99.68%
Pathak et al., [65] (India)Classification (detection)852Automatic feature extractionTransfer learning techniqueResNet-50CT imagesAccuracy: 93.01%
Waheed et al., [39] (India)Detection1124Automatic feature extractionGAN (CovidGAN)ACGAN3, VGG-16X-rayAccuracy: 95%, sensitivity: 90%, specificity: 97%
Pereira et al., [49] (Brazil)Diagnosis (classification)1144Automatic feature extractionDeep learning (CNN)Inception-V3X-rayF1 score: 89%
Mei et al., [48] (USA)Diagnosis905Automatic feature extractionDeep learning (CoroNet)Inception_ResNet_V2CT imagesCorrectly identifying 17 of 25 (68%) patients, whereas radiologists classified all of these patients as COVID-19 negative
Brunese et al., [31] (Italy)Detection and diagnosis6523Automatic feature extractionDeep learning (CoroNet)VGG-16X-rayAccuracy: 96.3%
Apostolopoulos et al., [29] (Greece)Detection455Automatic feature extractionDeep learning (CoroNet)MobileNetV2X-raySensitivity: 97.36%, specificity: 99.42%, accuracy: 99.18%
Elaziz et al., [60] (Egypt)Detection2 databases (open source)FrMEMs4Deep learning (CoroNet)MobileNetX-rayAccuracy for first dataset: 96.09%, accuracy for second dataset: 98.09%

1Bidirectional generative adversarial network. 2Neural architecture search network. 3Auxiliary classifier generative adversarial network. 4Fractional multichannel exponent moments (FrMEMs).