[Retracted] Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

Figure 1

Comparison of blood lipid levels, MAP, TLR2 and expressions of inflammatory factors, and changes of gene expression in each group. (a) Comparison of blood lipid levels: the concentration of TC and LDL in serum was lower in high fat-Ang II group and high-fat group than that in the control group, and the difference in the concentration of triglyceride and HDL was not statistically significant compared to the control group. (b) Comparison of MAP levels in each group: high fat-Ang II group had significantly higher MAP than high-fat group after the construction of the model, and in the meantime, MAP in the two groups was significantly higher than that in the control group. (c) Comparison of TLR2 and proinflammatory factor levels in serum of each group: TLR2 and proinflammatory factor levels were significantly higher in high-fat group than those in the control group, and TLR2 and IL-1β, IL-6, TNF-α, and CCL2 levels did not significantly increase compared to the control group, while CCL2 levels were not statistically significant compared to the control groups. (d) Heat map of gene expression abundance detected by qPCR showed significantly lower genes related to fatty acid oxidation, fatty hydrolysis, and cholesterolosis in high fat-Ang II group and high-fat group compared with the control groups (n = 5; ).

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