[Retracted] Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

Figure 2

Changes of MAP, blood lipid levels, TLR2 in serum and inflammatory factor concentrations, and lipid metabolism-related gene expression between Tlr2^-/--high fat-Ang II group and wild-high lipid-Ang II groups. (a) Comparison of MAP in Tlr2^-/--high fat-Ang II group and wild-high fat-Ang II group, MAP after the construction of the model was significantly lower in the Tlr2^-/--high fat-Ang II group than that in the wild-high fat-Ang II group. (b) Comparison of lipids and apolipoproteins in serum in Tlr2^-/--high fat-Ang II group and wild-high fat-Ang II group, TC and LDL in serum significantly decreased in the Tlr2^-/--high fat-Ang II group compared to the wild-high fat-Ang II group, while there was no significantly statistical difference between triglyceride and HDL between the two groups. (c) Tlr2^-/--high fat-Ang II group was not detected TLR2 in serum; at the same time, the levels of IL-1β and TNF-α were significantly lower than those in wild-high fat-Ang II group, with no statistical difference in IL-6 and CCL2 concentrations in serum than those in the wild-high fat-Ang II group. (d) Heat map of gene expression abundance detected by qPCR showed significantly increased related gene expressions of fatty acid oxidation, fat hydrolysis, and cholesterol hydrolysis in the Tlr2^-/--high fat-Ang II group compared to the wild-high fat-Ang II group (n = 5; ).

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