[Retracted] Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism

Figure 4

Changes of Akt pathway protein, MAP, lipid level, and apolipoprotein level, TLR2 and inflammatory factors compared those after blocking the Akt pathway. (a) The expression of p-Akt, t-Akt proteins in the wild-high fat-Ang II-CCT128930 group was significantly lower than that in wild-high fat-Ang II group. (b) After the construction of the model, MAP in the wild-high fat-Ang II-CCT128930 group significantly decreased compared with that in the wild-high fat-Ang II group. (c) The TC and LDL in serum decreased significantly in wild-high fat-Ang II-CCT128930 group and wild-high fat-Ang II group compared with those in the wild-high fat-Ang II group, but there was no significantly statistical difference in triglyceride and HDL between the two groups. (d) Comparison of serum levels of TLR2 and proinflammatory factor in each group. The concentration of IL-1β, TNF-α, and CCL2 in serum significantly decreased in the wild-high fat-Ang II-CCT128930 group compared with that in the wild-high fat-Ang II group, with no statistical difference in the concentration of TLR2 and IL-6 (n = 5; ).

(a)

(b)

(c)

(d)