Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma

Table 2

Univariate and multivariable analyses of prognostic factors for PSRCC patients.

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI	value	HR	95%CI	value
Gender
Female	Reference
Male	0.745	0.498∼1.116	0.153
Age, y
<60	Reference
≥60	0.857	0.586∼1.253	0.425
Race
White	Reference
Black	1.550	0.864∼2.782	0.142
Other	0.795	0.323∼1.961	0.619
AJCC 6th stage
I	Reference
II	1.395	0.590∼3.301	0.448
III	1.900	0.814∼4.437	0.138
IV	2.836	1.286∼6.254	0.010
AJCC 6th T stage
T1	Reference			Reference
T2	1.349	0.636∼2.861	0.435	1.623	0.744∼3.541	0.224
T3	1.785	0.845∼3.772	0.129	4.306	1.770∼10.478	0.001
T4	1.796	0.869∼3.711	0.114	2.765	1.218∼6.277	0.015
AJCC 6th N stage
N0	Reference			Reference
None N0	1.339	0.910∼1.971	0.139	1.275	0.772∼2.108	0.343
AJCC 6th M stage
M0	Reference			Reference
M1	2.915	1.832∼4.637	＜0.001	2.343	1.334∼4.118	0.003
Histologic grade
≤III	Reference			Reference
IV	0.750	0.490∼1.148	0.185	0.996	0.618∼1.603	0.986
Tumor size, mm
<100	Reference			Reference
100∼200	1.962	0.834∼4.619	0.123	1.324	0.516∼3.398	0.559
Unknown	1.834	1.237∼2.718	0.003	1.268	0.802∼2.004	0.310
Year of diagnosis
2004∼2009	Reference
2010∼2015	0.875	0.599∼1.276	0.487
Surgery
None	Reference			Reference
TURB	0.226	0.107∼0.477	＜0.001	0.255	0.109∼0.601	0.002
Partial cystectomy	0.111	0.042∼0.295	＜0.001	0.125	0.040∼0.389	＜0.001
Radical cystectomy	0.155	0.072∼0.335	＜0.001	0.193	0.080∼0.467	＜0.001
Pelvic exenteration	0.129	0.058∼0.289	＜0.001	0.132	0.049∼0.354	＜0.001
Other	0.138	0.046∼0.419	＜0.001	0.129	0.039∼0.424	0.001
Lymph nodes removed
None	Reference			Reference
1 to 3 regional	1.494	0.467∼4.778	0.499	0.683	0.179∼2.615	0.578
4 or more regional	0.566	0.384∼0.835	0.004	0.477	0.247∼0.922	0.028