[Retracted] COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage

Figure 4

Brain edema and BBB permeability of mice in each group. (a) Brain water content measurement showed that obvious brain edema occurred in the SAH group and COG133 inhibited the brain edema. (b) Brain EB content detection showed that BBB permeability was significantly increased after SAH, and COG133 treatment decreased the BBB permeability. (c, d) Lectin/IgG coimmunofluorescence staining and Lectin/IgG copositive cells rate showed that IgG extravascular leakage after SAH was inhibited by COG133 treatment. RH, right hemisphere, LH, left hemisphere.  < 0.01,  < 0.001, and  < 0.0001 vs Sham group,  < 0.01,  < 0.001, and  < 0.0001 vs SAH group.

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