[Retracted] COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage

Figure 5

The tight junction injury of BBB after SAH. (a) The western blotting assay showed that the expressions of TJPs (ZO-1, occludin, and claudin-5) were obviously downregulated after SAH but upregulated by COG133 treatment. (b) Representative images of brain tissue TEM. The results showed there were large numbers of tight junction disruptions (red arrows) and COG133 reduced the disruptions of tight junction between endothelial cells. Blood cells. Red arrows showed the disruptions of the tight junction.  < 0.01,  < 0.001, and  < 0.0001 vs Sham group,  < 0.01,  < 0.001, and  < 0.0001 vs SAH group.

(a)

(b)