[Retracted] COG133 Attenuates the Early Brain Injury Induced by Blood-Brain Barrier Disruption in Experimental Subarachnoid Hemorrhage

Figure 6

Expression of the proteins in CypA-NF-κB-MMP9 pathway. (a) The expressions of CypA and p-p65 showed an increase after SAH, while COG133 treatment inhibited the expressions of CypA and p-p65. (b) There was a significant increase in the level of MMP9 after SAH, and COG133 downregulated the expression of MMP9. (c) The representative images of brain MMP9/Lectin coimmunofluorescence staining. (d, e) ELISA assay showed the levels of proinflammatory cytokines, IL-6 and TNF-α, were increased in the SAH group and decreased by COG133 treatment.  < 0.05,  < 0.01,  < 0.001, and  < 0.0001 vs Sham group,  < 0.05,  < 0.01,  < 0.001, and  < 0.0001 vs SAH group.

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