A Study on Early Death Prognosis Model in Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis
Table 2
Prognostic factors of overall survival of 139 patients with sHLH.
Univariate analysis
Multivariate analysis
8-week OS
HR
95% CI
WBC (×109/L)
0.024
<2
57.6%
HGB (g/L)
<0.001
<80
46.3%
PLT (×109/L)
0.003
<30
50.0%
CRP (mg/L)
0.023
>25
77.1%
γ-GT (U/L)
0.05
>200
73.9%
TBil (umol/L)
0.015
>20
79.3%
Alb (g/L)
0.005
<30
58.0%
BUN (mmol/L)
0.015
>6
74.7%
Ca (mmol/L)
<0.001
0.305
0.047
0.094-0.986
<1.8
30.0%
Na (mmol/L)
0.033
<135
57.4%
sCD25 (pg/ml)
0.005
>30000
82.1%
EBV (copy/ml)
0.008
> 6.5E+003
76.7%
D-Dimer (mg/L)
0.002
>3.6
77.5%
Cardiac Impairment
0.003
Yes
48.3%
Visceral Hemorrhage
0.003
2.746
0.041
1.041–7.242
Yes
46.4%
CNS Involvement
0.001
Yes
44.8%
response to induction therapy
<0.001
0.122
0.004
0.029–0.509
CR
89.1%
0.291
0.043
0.088–0.960
PR
68%
NR
44.2%
Abbreviation: OS, overall survival; HR, hazard ratio; < 0.05; < 0.01, variables used in multivariate analysis were selected after excluding significant correlations: Ca, visceral hemorrhage, response to induction therapy.