A Study on Early Death Prognosis Model in Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis

Table 2

Prognostic factors of overall survival of 139 patients with sHLH.

Univariate analysis			Multivariate analysis
	8-week OS		HR		95% CI
WBC (×10^9/L)		0.024
<2	57.6%
HGB (g/L)		<0.001
<80	46.3%
PLT (×10^9/L)		0.003
<30	50.0%
CRP (mg/L)		0.023
>25	77.1%
γ-GT (U/L)		0.05
>200	73.9%
TBil (umol/L)		0.015
>20	79.3%
Alb (g/L)		0.005
<30	58.0%
BUN (mmol/L)		0.015
>6	74.7%
Ca (mmol/L)		<0.001	0.305	0.047	0.094-0.986
<1.8	30.0%
Na (mmol/L)		0.033
<135	57.4%
sCD25 (pg/ml)		0.005
>30000	82.1%
EBV (copy/ml）		0.008
> 6.5E+003	76.7%
D-Dimer (mg/L)		0.002
>3.6	77.5%
Cardiac Impairment		0.003
Yes	48.3%
Visceral Hemorrhage		0.003	2.746	0.041	1.041–7.242
Yes	46.4%
CNS Involvement		0.001
Yes	44.8%
response to induction therapy		<0.001	0.122	0.004	0.029–0.509
CR	89.1%		0.291	0.043	0.088–0.960
PR	68%
NR	44.2%

Abbreviation: OS, overall survival; HR, hazard ratio;  < 0.05;  < 0.01, variables used in multivariate analysis were selected after excluding significant correlations: Ca, visceral hemorrhage, response to induction therapy.