Quantitative Scintigraphy Evaluated the Relationship between 131I Therapy and Salivary Glands Function in DTC Patients: A Retrospective Analysis

Table 3

Comparison of salivary gland function in patients before third treatment.

Scintigraphic parameters

Male group before third treatment

Female group before third treatment

Damage before treatment

After first treatment

After second treatment

No damage before treatment

After first treatment

After second treatment

Damage before treatment

After first treatment

After second treatment

No damage before treatment

After first treatment

After second treatment

RP

Number: 2

Number: 29

Number: 2

Number: 86

UF

0.034 (0.018–0.033)

0.057 (0.019–0.067)

0.044 (0.012–0.055)

0.223

0.050 (0.031–0.068)

0.049 (0.032–0.060)

0.043 (0.026–0.061)

0.485

0.037 (0.010–0.045)

0.033 (0.010–0.039)

0.028 (0.008–0.034)

0.135

0.042 (0.031–0.055)

0.037 (0.028–0.048)

0.032 (0.021–0.041)

0.000

III-II 0.005 III-I 0.000 ⋯ II-I 0.081

UI

1.844 (1.054–1.712)

2.967 (0.865–3.586)

2.387 (0.864–2.717)

0.607

1.867 (1.527–2.391)

1.898 (1.440–2.819)

2.016 (1.277–3.038)

0.485

1.356 (0.673–1.360)

1.247 (0.533–1.336)

1.464 (0.588–1.607)

0.223

1.952 (1.549–2.479)

1.789 (1.460–2.188)

1.581 (1.137–2.102)

0.000

III-II 0.014 III-I 0.000 II-I 0.098

EF

0.254 (0.064–0.317)

0.506 (0.304–0.455)

0.299 (0.148–0.300)

0.607

0.486 (0.433–0.544)

0.478 (0.352–0.581)

0.493 (0.340–0.579)

0.422

0.194 (0.055–0.237)

0.418 (0.221–0.406)

0.412 (0.222–0.395)

1.000

0.485 (0.415–0.552)

0.4715 (0.419–0.539)

0.420 (0.246–0.521)

0.002

III-II0.036 III-I 0.002 II-I 1.000

LP

No case

Number: 31

Number: 5

Number: 83

UF

0.041 (0.035–0.065)

0.045 (0.033–0.056)

0.036 (0.027–0.053)

0.206

0.019 (0.009–0.025)

0.025 (0.021–0.039)

0.021 (0.013–0.040)

0.165

0.040 (0.029–0.051)

0.034 (0.027–0.045)

0.032 (0.021–0.042)

0.000

III-II 0.309 III-I 0.000 II-I 0.016

UI

1.971 (1.523–2.460)

1.897 (1.348–2.457)

1.615 (1.359–2.576)

0.597

0.861 (0.687–1.776)

1.164 (1.010–1.879)

1.332 (.916–2.084)

0.247

2.006 (1.393–2.281)

1.717 (1.319–2.143)

1.686 (1.231–2.194)

0.008

III-II 1.000 III-I 0.020 II-I 0.025

EF

0.510 (0.442–0.558)

0.464 (0.402–0.550)

0.455 (0.347–0.545)

0.086

0.166 (0.102–0.382)

0.368 (0.292–0.439)

0.328 (0.173–0.458)

0.247

0.479 (0.420–0.544)

0.472 (0.394–0.523)

0.423 (0.326–0.514)

0.010

III-II 0.392 III-I 0.008 II-I 0.392

RS

Number: 2

Number: 29

Number: 6

Number: 82

UF

0.034 (0.017–0.033)

0.033 (0.016–0.034)

0.032 (0.021–0.027)

1.000

0.058 (0.046–0.080)

0.054 (0.042–0.066)

0.051 (0.038–0.065)

0.018

0.050 (0.033–0.064)

0.044 (0.032–0.068)

0.044 (0.018–0.074)

0.607

0.052 (0.039–0.068)

0.048 (0.035–0.057)

0.043 (0.034–0.054)

0.000

III-II 1.000 III-I 0.017 II-I 0.147

III-II 0.823 III-I 0.000 II-I 0.004

UI

1.553 (0.664–1.665)

1.821 (0.961–1.770)

1.636 (1.189–1.265)

0.607

3.171 (2.438–3.936)

3.105 (2.284–3.663)

3.052 (2.415–3.624)

0.639

1.650 (1.266–2.771)

2.251 (2.099–3.090)

2.024 (1.318–3.273)

0.115

2.685 (2.161–3.528)

2.715 (2.021–3.318)

2.395 (2.010–3.092)

0.011

III-II 0.930 III-I 0.009 II-I 0.153

EF

0.096 (0.029–0.115)

0.122 (0.038–0.146)

0.073 (0.032–0.078)

0.223

0.381 (0.335–0.467)

0.375 (0.271–0.416)

0.396 (0.318–0.468)

0.343

0.159 (0.122–0.169)

0.339 (0.248–0.382)

0.343 (0.191–0.439)

0.042

0.404 (0.308–0.498)

0.367 (0.291–0.435)

0.332 (0.242–0.430)

0.000

III-II 0.773 III-I 0.021 II-I 0.043 ^b

III-II 0.414 III-I0 .000 II-I0 .024

LS

Number: 2

Number: 29

Number: 9

Number: 79

UF

0.031 (0.011–0.036)

0.033 (0.009–0.040)

0.023 (0.009–0.025)

0.607

0.056 (0.044–0.079)

0.048 (0.040–0.065)

0.050 (0.040–0.059)

0.024

0.033 (0.023–0.051)

0.034 (0.020–0.040)

0.030 (0.021–0.043)

0.895

0.050 (0.039–0.068)

0.045 (0.034–0.055)

0.041 (0.033–0.054)

0.000

III-II 1.000 III-I 0.018 II-I 0.018

III-II0.529 III-I 0.000 II-I 0.016

UI

1.482 (0.656–1.568)

1.570 (0.645–1.711)

1.030 (0.421–1.125)

0.223

3.584 (2.667–4.089)

3.236 (2.655–3.797)

3.053 (2.546–3.685)

0.166

1.891 (1.437–2.864)

2.019 (1.591–2.928)

1.932 (1.408–2.687)

0.641

2.979 (2.219–3.580)

2.687 (2.140–3.362)

2.542 (1.977–3.191)

0.003

III-II 1.000 III-I 0.003 II-I .051

EF

0.169 (0.123–0.131)

0.072 (0.000–0.108)

0.034 (0.016–0.034)

0.223

0.418 (0.316–0.492)

0.372 (0.295–0.436)

0.404 (0.321–0.528)

0.166

0.169 (0.119–0.199)

0.336 (0.229–0.386)

0.235 (0.165–0.386)

0.050

0.395 (0.300–0.499)

0.365 (0.273–0.444)

0.323 (0.233–0.435)

0.000

UF, UI, EF stated as median (upper quartile, lower quartiles). Examination before first, second and third treatments expressed as I, II, and III. The values were p values after pairwise comparison of I, II, III. RP: Right parotid; LP: Left parotid; RS: Right submandibular; LS: Left submandibular; UF: Uptake fraction; UI: Uptake index; EF: Excretion fraction.