Nomogram Models Based on the Gene Expression in Prediction of Breast Cancer Bone Metastasis

Figure 5

Gene expression signature-based nomogram models and decision curve analysis (DCA). (a) The four-gene-based nomogram model based on overall survival (OS). (b) The six-gene-based nomogram model based on progression-free survival (PFS). (c) DCA for the nomogram model based on OS. Model 1: GJA1; model 2: GJA1 + SLC24A3; model 3: nomogram. (d) DCA for the nomogram model based on PFS. Model 1: IGFBP6 + GJA1; model 2: IGFBP6 + GJA1 + TGFBI + MDFI; model 3: nomogram. (e) Construction of nomogram model for predicting bone metastasis. PR status, progesterone receptor status, 0: negative, 1: positive; PES, prior endocrine sensitivity.

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