Identification and Validation of a Gene Signature for Lower-Grade Gliomas Based on Pyroptosis-Related Genes to Predict Survival and Response to Immune Checkpoint Inhibitors

Figure 9

LGG patients’ response to ICIs and PRS gene signature. (a) The expressions of 11 ICs between the low-risk group and high-risk group in TCGA. (b) The expressions of 11 ICs between the low-risk group and high-risk group in CGGA. (c-e) The MHC score, EC score, and SC score between the low-risk group and high-risk group. (f) Risk score in LGG patients with a different ICI response status. (g-j) The MIAS, GEP score, IPS, and IMPRES between the low-risk group and high-risk group. Data in (a-b) were analyzed by Wilcoxon test; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, and ^∗∗∗∗p < 0.0001.

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