Advanced dental biomaterials are rapidly improving the quality of clinical applications within the main branches of dentistry. Oral Tissue Engineering (OTE) belongs to the wider field of regenerative medicine, a miscellaneous area that embraces interdisciplinary fields of research with interesting clinical applications. OTE is mainly focused on reparation and substitution, as well as the regeneration of oral tissues and organs, aiming at their rehabilitation, restoring both function and anatomy. The healing of damaged tissues is commonly induced by physiological processes that successfully merge biomaterials, 3D scaffolds, growth factors, and stem cells together.

Functional biomaterials represent the latest development of bioactive materials: they have been investigated and improved, especially in dental applications, demonstrating promising results on oral tissue healing and rehabilitation. Oral Tissue Engineering plays a pivotal role in the continuous development of novel biomaterials: the future challenges are based on the discovery of smart biomaterials, able not only to replace and/or restore dental tissues, but also to mimic their biological features, thus ensuring successful treatment in several dental applications.

The aim of this Special Issue is to provide an updated and highly impacted overview of the current best performers and future perspectives related to new treatment modalities related to dental diseases. Debates on the role of scaffolds in bone regeneration, periodontics, composite materials for dental restorations and biomaterials for oral tissue rehabilitation are highly welcome. Papers should also cover the current developments and newer treatment modalities in the treatment of dental diseases, biomaterials design, material-to-tissue interaction, and tissue self-repairing, periodontal healing. Authors are invited to focus their attention on bioactive materials, nanotechnologies and interdisciplinary research. We welcome original research and review articles.

Potential topics include but are not limited to the following:

• New treatment modalities in dental and oral disease
• Regenerative dentistry with gene therapy and growth factors
• Oral Tissue Engineering with stem cells, biomaterials and additive manufacturing
• Advances in oral rehabilitation, new diagnostic tools and biomaterial/tissue interactions
• Advanced management of periodontal diseases
• New advancements in the management of dental caries and pulp and periapical lesions.
• Alveolar bone grafting and distraction osteogenesis
• Surface modification of dental implants
• Tissue engineering of temporomandibular joints, skin and oral mucosa and salivary glands
• Oral cancer new diagnostics and management approaches, head and neck cancer new modalities and treatment options