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Developmental Immunology
Volume 1, Issue 3, Pages 237-242
http://dx.doi.org/10.1155/1991/95302
Short Communication

Developmental Expression of IL-2-Receptor Light Chain (CD25) in the Chicken Embryo

1Institut d'Embryologie du CNRS et du Collège de France, 49bis avenue de la Belle Gabrielle, F-94736 Nogent-sur-Marne, Paris Cedex, France
2Ontario Cancer Institute, 500 Sherbourne Street, Ontario, Toronto M4X 1K9, Canada
3Centro de Biología Molecular, CSIC, Universidad Autónoma, Campus de Cantoblanco, Madrid 28049, Spain

Received 16 November 1990; Accepted 16 November 1990

Copyright © 1991 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thymocyte differentiation obeys the same fundamental principles in mammals as in avian species. This parallelism does not only affect the developmentally controlled acquisition of CD3, 4, 8, and TcR isotype expression, but also concerns CD25, the light chain of the interleukin-2 receptor (IL-2R). On chicken thymocytes, surface CD25, which is recognized by the monoclonal antibody INN Ch16, is first observed during day 11 of embryonic life, and peaks at day 14, when it is expressed by about one-third of all lymphoid cells. CD25 is found on subsets of all ,thymocyte populations as defined by TcRαβ, TcRγδ, 2, CD4, and CD8 expression, cortical or medullary localization, and is also present on a subset of intrathymic nurse-cell lymphocytes. These findings suggest phylogenetic conservation of the IL-2/IL-2R-triggered differentiation pathway previously described for mammalian species, thus under-lining its probable functional importance.