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Developmental Immunology
Volume 2 (1992), Issue 2, Pages 141-150
http://dx.doi.org/10.1155/1992/57057

The Involvement of the Intestinal Microflora in the Expansion of CD4+ T Cells with a-Naive Phenotype in the Periphery

1Section of Immunology, Institute of Ageing and Vascular Research TNO, P.O. Box 430, Leiden 2300 AK, The Netherlands
2Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [56 citations]

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  • A Hertoghhuijbregts, and L Nagelkerken, “The Acquisition Of A Memory Phenotype By Murine Cd4+ T-Cells Is Accompanied By A Loss In Their Capacity To Increase Intracellular Calcium,” Developmental Immunology, vol. 3, no. 1, pp. 25–34, 1992. View at Publisher · View at Google Scholar
  • J Schuitemaker, R Dobber, M Tielemans, P Vandenbergh, and L Nagelkerken, “The Sensitivity Of Il-4 Production For Camp Inducers Is Lost In Cd4+ T-Cells From Aged Mice,” International Immunology, vol. 5, no. 9, pp. 1167–1176, 1993. View at Publisher · View at Google Scholar
  • H Deweerd, R Dobber, M Tielemans, and L Nagelkerken, “Mel14+ Cd4+ T-Cells From Aged Mice Display Functional And Phenotypic Characteristics Of Memory Cells,” International Immunology, vol. 6, no. 8, pp. 1227–1234, 1994. View at Publisher · View at Google Scholar
  • J. Rozing, and B. de Geus, “Changes in the Intestinal Lymphoid Compartment Throughout Life: Implications for the Local Generation of Intestinal T Cells,” International Reviews of Immunology, vol. 12, no. 1, pp. 13–25, 1995. View at Publisher · View at Google Scholar
  • C.R. Mainhart, J. Sopher, Sandra J. Smith-Gill, Ann H. McDonald, and Linda G. Byrd, “Plasmacytoma-refractory BALB/cAnPt mice have naive T cell and highly specific B cell responses to antigen,” Molecular Immunology, vol. 33, no. 15, pp. 1183–1196, 1996. View at Publisher · View at Google Scholar
  • Lukas Cederbom, Antonio Bandeira, Antonio Coutinho, and Fredrik Ivars, “Naturally activated CD4+ T cells are highly enriched for cytokine-producing cells,” European Journal of Immunology, vol. 28, no. 6, pp. 1934–1940, 1998. View at Publisher · View at Google Scholar
  • M. Elwood Clive, and A. Garden Oliver, “Gastrointestinal Immunity in Health and Disease,” Veterinary Clinics of North America: Small Animal Practice, vol. 29, no. 2, pp. 471–500, 1999. View at Publisher · View at Google Scholar
  • J. E. Butler, J. Sun, P. Weber, P. Navarro, and D. Francis, “Antibody repertoire development in fetal and newborn piglets, III. Colonization of the gastrointestinal tract selectively diversifies the preimmune repertoire in mucosal lymphoid tissues,” Immunology, vol. 100, no. 1, pp. 119–130, 2000. View at Publisher · View at Google Scholar
  • Hisakata Yamada, Goro Matsuzaki, QiJie Chen, Yukihide Iwamoto, and Kikuo Nomoto, “Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells,” European Journal of Immunology, vol. 31, no. 6, pp. 1917–1926, 2001. View at Publisher · View at Google Scholar
  • D Masopust, L Lefrancois, V Vezys, and Al Marzo, “Preferential localization of effector memory cells in nonlymphoid tissue,” Science, vol. 291, no. 5512, pp. 2413–2417, 2001. View at Publisher · View at Google Scholar
  • R Duarte, Am Silva, Lq Vieira, Lcc Afonso, and Jr Nicoli, “Influence of normal microbiota on some aspects of the immune response during experimental infection with Trypanosoma cruzi in mice,” Journal Of Medical Microbiology, vol. 53, no. 8, pp. 741–748, 2004. View at Publisher · View at Google Scholar
  • Sarkis K. Mazmanian, Cui Hua Liu, Arthur O. Tzianabos, and Dennis L. Kasper, “An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System,” Cell, vol. 122, no. 1, pp. 107–118, 2005. View at Publisher · View at Google Scholar
  • Charles D. Surh, and Jonathan Sprent, “Regulation of mature T cell homeostasis,” Seminars in Immunology, vol. 17, no. 3, pp. 183–191, 2005. View at Publisher · View at Google Scholar
  • Sun-Kyeong Lee, and Charles D. Surh, “Role of interleukin-7 in bone and T-cell homeostasis,” Immunological Reviews, vol. 208, no. 1, pp. 169–180, 2005. View at Publisher · View at Google Scholar
  • R. Duarte, A.M. Silva, L.Q. Vieira, L.C.C. Afonso, and J.R. Nicoli, “Trypanosoma cruzi: Influence of predominant bacteria from indigenous digestive microbiota on experimental infection in mice,” Experimental Parasitology, vol. 111, no. 2, pp. 87–96, 2005. View at Publisher · View at Google Scholar
  • Charles D. Surh, Onur Boyman, Jared F. Purton, and Jonathan Sprent, “Homeostasis of memory T cells,” Immunological Reviews, vol. 211, no. 1, pp. 154–163, 2006. View at Publisher · View at Google Scholar
  • Sarkis K. Mazmanian, and Dennis L. Kasper, “The love–hate relationship between bacterial polysaccharides and the host immune system,” Nature Reviews Immunology, vol. 6, no. 11, pp. 849–858, 2006. View at Publisher · View at Google Scholar
  • Jianfang Hu, Nisebita Sahu, Elizabeth Walsh, and Avery August, “Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk,” European Journal of Immunology, vol. 37, no. 10, pp. 2892–2899, 2007. View at Publisher · View at Google Scholar
  • B. Metzler, P. Gfeller, G. Wieczorek, J. Li, B. Nuesslein-Hildesheim, A. Katopodis, M. Mueller, and V. Brinkmann, “Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure,” International Immunology, vol. 20, no. 5, pp. 633–644, 2008. View at Publisher · View at Google Scholar
  • J. Leignadier, M.-P. Hardy, M. Cloutier, J. Rooney, and N. Labrecque, “Memory T-lymphocyte survival does not require T-cell receptor expression,” Proceedings of the National Academy of Sciences, vol. 105, no. 51, pp. 20440–20445, 2008. View at Publisher · View at Google Scholar
  • Tomas Hrncir, Renata Stepankova, Hana Kozakova, Tomas Hudcovic, and Helena Tlaskalova-Hogenova, “Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice,” Bmc Immunology, vol. 9, 2008. View at Publisher · View at Google Scholar
  • Akira Motegi, Manabu Kinoshita, Akihito Inatsu, Yoshiko Habu, Daizoh Saitoh, and Shuhji Seki, “IL-15-induced CD8+CD122+ T cells increase antibacterial and anti-tumor immune responses: Implications for immune function in aged mice,” Journal of Leukocyte Biology, vol. 84, no. 4, pp. 1047–1056, 2008. View at Publisher · View at Google Scholar
  • Erin K. Rottinghaus, Bridget Vesosky, and Joanne Turner, “Interleukin-12 is sufficient to promote antigen-independent interferon-γ production by CD8 T cells in old mice,” Immunology, vol. 128, no. 1pt2, pp. e679–e690, 2009. View at Publisher · View at Google Scholar
  • Momoe Itsumi, Yasunobu Yoshikai, and Hisakata Yamada, “IL-15 is critical for the maintenance and innate functions of self-specific CD8+ T cells,” European Journal of Immunology, vol. 39, no. 7, pp. 1784–1793, 2009. View at Publisher · View at Google Scholar
  • Sebastian Fraune, and Thomas C. G. Bosch, “Why bacteria matter in animal development and evolution,” BioEssays, vol. 32, no. 7, pp. 571–580, 2010. View at Publisher · View at Google Scholar
  • June L. Round, Ryan M. O'Connell, and Sarkis K. Mazmanian, “Coordination of tolerogenic immune responses by the commensal microbiota,” Journal of Autoimmunity, vol. 34, no. 3, pp. J220–J225, 2010. View at Publisher · View at Google Scholar
  • Lisa Colleen Osborne, and Ninan Abraham, “Regulation of memory T cells by γc cytokines,” Cytokine, vol. 50, no. 2, pp. 105–113, 2010. View at Publisher · View at Google Scholar
  • Y. K. Lee, and S. K. Mazmanian, “Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?,” Science, vol. 330, no. 6012, pp. 1768–1773, 2010. View at Publisher · View at Google Scholar
  • Jonathan Sprent, and Charles D Surh, “Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells,” Nature Immunology, vol. 131, no. 6, pp. 478–484, 2011. View at Publisher · View at Google Scholar
  • Gabriele Hrmannsperger, Thomas Clavel, and Dirk Haller, “Gut matters: Microbe-host interactions in allergic diseases,” Journal of Allergy and Clinical Immunology, vol. 129, no. 6, pp. 1452–1459, 2012. View at Publisher · View at Google Scholar
  • Klara Sjögren, Cecilia Engdahl, Petra Henning, Ulf H Lerner, Valentina Tremaroli, Marie K Lagerquist, Fredrik Bäckhed, and Claes Ohlsson, “The gut microbiota regulates bone mass in mice,” Journal of Bone and Mineral Research, vol. 27, no. 6, pp. 1357–1367, 2012. View at Publisher · View at Google Scholar
  • Charlotte F. Inman, Georgina M. Laycock, Louisa Mitchard, Ross Harley, James Warwick, Rachel Burt, Pauline M. van Diemen, Mark Stevens, and Mick Bailey, “Neonatal Colonisation Expands a Specific Intestinal Antigen-Presenting Cell Subset Prior to CD4 T-Cell Expansion, without Altering T-Cell Repertoire,” Plos One, vol. 7, no. 3, 2012. View at Publisher · View at Google Scholar
  • Marie-Claire Arrieta, and Barton Brett Finlay, “The commensal microbiota drives immune homeostasis,” Frontiers In Immunology, vol. 3, 2012. View at Publisher · View at Google Scholar
  • S. Franzenburg, J. Walter, S. Kunzel, J. Wang, J. F. Baines, T. C. G. Bosch, and S. Fraune, “Distinct antimicrobial peptide expression determines host species-specific bacterial associations,” Proceedings of the National Academy of Sciences, vol. 110, no. 39, pp. E3730–E3738, 2013. View at Publisher · View at Google Scholar
  • D. J. Johnson, L. I. Pao, S. Dhanji, K. Murakami, P. S. Ohashi, and B. G. Neel, “Shp1 regulates T cell homeostasis by limiting IL-4 signals,” Journal of Experimental Medicine, vol. 210, no. 7, pp. 1419–1431, 2013. View at Publisher · View at Google Scholar
  • Holger Garn, Joana F. Neves, Richard S. Blumberg, and Harald Renz, “Effect of barrier microbes on organ-based inflammation,” Journal of Allergy and Clinical Immunology, vol. 131, no. 6, pp. 1465–1478, 2013. View at Publisher · View at Google Scholar
  • Hisakata Yamada, Kensuke Shibata, Koji Sakuraba, Kenjiro Fujimura, and Yasunobu Yoshikai, “ Positive selection of self-antigen-specific CD8 + T cells by hematopoietic cells ,” European Journal of Immunology, 2013. View at Publisher · View at Google Scholar
  • Sathyaseelan Sathyabama, Nargis Khan, and Javed N. Agrewala, “Friendly pathogens: prevent or provoke autoimmunity,” Critical Reviews in Microbiology, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  • Rebecca M. Stumpf, Brenda A. Wilson, Angel Rivera, Suleyman Yildirim, Carl J. Yeoman, John D. Polk, Bryan A. White, and Steven R. Leigh, “The primate vaginal microbiome: Comparative context and implications for human health and disease,” American Journal of Physical Anthropology, 2013. View at Publisher · View at Google Scholar
  • Kristine A. Kuhn, and Thaddeus S. Stappenbeck, “Peripheral education of the immune system by the colonic microbiota,” Seminars in Immunology, 2013. View at Publisher · View at Google Scholar
  • Sema Kurtulus, Pulak Tripathi, and David A. Hildeman, “Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development,” Frontiers In Immunology, vol. 3, 2013. View at Publisher · View at Google Scholar
  • Abolfazl Barzegari, Nazli Saeedi, and Amir Ata Saei, “Shrinkage of the human core microbiome and a proposal for launching microbiome biobanks,” Future Microbiology, vol. 9, no. 5, pp. 639–656, 2014. View at Publisher · View at Google Scholar
  • Sebastian Fraune, Friederike Anton-Erxleben, René Augustin, Sören Franzenburg, Mirjam Knop, Katja Schröder, Doris Willoweit-Ohl, and Thomas CG Bosch, “Bacteria–bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance,” The ISME Journal, 2014. View at Publisher · View at Google Scholar
  • Sophie Yurist-Doutsch, Marie-Claire Arrieta, Stefanie L. Vogt, and B. Brett Finlay, “Gastrointestinal Microbiota–Mediated Control of Enteric Pathogens,” Annual Review of Genetics, vol. 48, no. 1, pp. 361–382, 2014. View at Publisher · View at Google Scholar
  • Wenliang Zhang, Vinayak Brahmakshatriya, and Susan L. Swain, “CD4 T cell Defects in the Aged: Causes, Consequences and Strategies to Circumvent,” Experimental Gerontology, 2014. View at Publisher · View at Google Scholar
  • Scott F. Gilbert, Thomas C. G. Bosch, and Cristina Ledón-Rettig, “Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents,” Nature Reviews Genetics, 2015. View at Publisher · View at Google Scholar
  • Jia Y. Har, Tim Helbig, Ju H. Lim, Samodha C. Fernando, Adam M. Reitzel, Kevin Penn, and Janelle R. Thompson, “Microbial diversity and activity in the Nematostella vectensis holobiont: insights from 16S rRNA gene sequencing, isolate genomes, and a pilot-scale survey of gene expression,” Frontiers in Microbiology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • William E. Ruff, and Martin A. Kriegel, “Autoimmune host–microbiota interactions at barrier sites and beyond,” Trends in Molecular Medicine, 2015. View at Publisher · View at Google Scholar
  • Christopher R. Villa, Wendy E. Ward, and Elena M. Comelli, “Gut Microbiota-bone Axis,” Critical Reviews in Food Science and Nutrition, pp. 00–00, 2015. View at Publisher · View at Google Scholar
  • Takeshi Kawabe, Nobu Suzuki, Satoshi Yamaki, Shu-lan Sun, Atsuko Asao, Yuko Okuyama, Takanori So, Yoichiro Iwakura, and Naoto Ishii, “Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice,” European Journal of Immunology, vol. 46, no. 5, pp. 1119–1131, 2016. View at Publisher · View at Google Scholar
  • Emilia Pachulec, Vanessa Neitzke-Montinelli, and João P. B. Viola, “NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses,” Frontiers in Immunology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Dania Zhivaki, and Richard Lo-Man, “In utero development of memory T cells,” Seminars in Immunopathology, 2017. View at Publisher · View at Google Scholar
  • Chad M. Novince, Carolyn R. Whittow, Johannes D. Aartun, Jessica D. Hathaway, Nicole Poulides, Michael B. Chavez, Heidi M. Steinkamp, Kaeleigh A. Kirkwood, Emily Huang, Caroline Westwater, and Keith L. Kirkwood, “Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Jason T. White, Eric W. Cross, and Ross M. Kedl, “Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them,” Nature Reviews Immunology, 2017. View at Publisher · View at Google Scholar
  • Raymond Soto, Charisse Petersen, Camille L. Novis, Jason L. Kubinak, Rickesha Bell, W. Zac Stephens, Thomas E. Lane, Robert S. Fujinami, Alberto Bosque, Ryan M. O’Connell, and June L. Round, “Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor,” Proceedings of the National Academy of Sciences, pp. 201619336, 2017. View at Publisher · View at Google Scholar
  • Pedro Gonçalves, Marco Ferrarini, Carmen Molina-Paris, Grant Lythe, Florence Vasseur, Annik Lim, Benedita Rocha, and Orly Azogui, “A new mechanism shapes the naïve CD8 + T cell repertoire: The selection for full diversity,” Molecular Immunology, vol. 85, pp. 66–80, 2017. View at Publisher · View at Google Scholar