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Developmental Immunology
Volume 4, Issue 3, Pages 199-209
http://dx.doi.org/10.1155/1995/35075

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

1Laboratory for Foetal and Neonatal Immunology, The University of Melbourne, Cnr. Flemington Road and Park Drive, Parkville, Victoria 3052, Australia
2IGBMC, BP163, Illkirch Cedex, C.U. de Strasbourg 67404, France
3Department of Molecular Medicine, University of Auckland, New Zealand

Received 20 October 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on αβ and γδ T cells emigrating from the fetal and postnatal thymus. We report that both γδ and the CD4+ CD8- and CD4-CD8+ subsets of αβ T cells express mature levels of the adhesion molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas CD44 is up-regulated on γδ+ thymocytes prior to export, down-regulation of both CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that down-regulation of these molecules may be a final maturational step taken by developing γδ T cells before their export from the thymus. In contrast, there is continued up-regulation of CD2 on αβ and γδ T cells upon emigration from the thymus and as they move into the mature peripheral T-cell pool. There was also a marked reduction in the number of CD2+γδ T cells exported during fetal development that was associated with a marked reduction in the percentage of CD22+γδ thymocytes exported. The postthymic maturation of CD2 and the other changes in adhesion-molecule expression appear to be independent of extrinsic antigen, as the same changes were observed in the antigen-free environment of the fetus as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that these changes in adhesion-molecule expression are as a result of the normal maturation pathway from a developing thymocyte to a mature peripheral T cell.