Journal of Immunology Research

Journal of Immunology Research / 1995 / Article

Open Access

Volume 4 |Article ID 038639 |

Melanie Wilson, Anne Marcuz, Louis Du Pasquier, "Somatic Mutations During an Immune Response in Xenopus Tadpoles", Journal of Immunology Research, vol. 4, Article ID 038639, 8 pages, 1995.

Somatic Mutations During an Immune Response in Xenopus Tadpoles

Received16 Feb 1995
Accepted05 May 1995


The tadpole B-cell repertoire is less diverse than that of the adult frog; their antibodies are of lower affinity and are less heterogenous. In order to determine whether this difference is due to a lack of or a reduced rate of somatic hypermutation, we analyzed and compared cDNA sequences utilizing VH1 elements with germline counterparts in isogenic LG7 tadpoles during an immune response. Indeed, tadpole VH1 sequences contained somatic mutations. There were zeo to 5 mutations per sequence, all single base-point mutations, with the high ratio of GC to AT base-pair alterations similar to that observed in adult frogs.

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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