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Developmental Immunology
Volume 9, Issue 3, Pages 143-149
http://dx.doi.org/10.1080/1044667031000137610

Kupffer Cell-mediated Recruitment of Dendritic Cells to the Liver Crucial for a Host Defense

1Department of Anatomy (Macro) and SORST, Dokkyo University, School of Medicine, Mibu 321-0293, Tochigi, Japan
2Department of Biochemistry I, Kumamoto University, School of Medicine, Kumamoto 860-0811, Japan
3Department of Molecular Preventive Medicine, School of Medicine and SORST, The University of Tokyo, Tokyo 113-0033, Japan

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tissue recruitment of dendritic cells (DCs) is essential for antigen presentation. When latex particulates were injected intravenously into rats, DC precursors were recruited to the liver. Propionibacterium acnes also induced the recruitment of definite mouse DC precursors. These DCs initially showed a selective binding to Kupffer cells. In the Kupffer cell-depleted rats, DCs could neither be recruited to the liver nor adhere to sinusoidal walls. Pretreatment with varied monosaccharides in vitro showed that sugar residues consisting of N-acetylgalactosamine were necessary for this binding. Mouse DC precursors had CC-chemokine receptor 1 and 5, while granulama tissues and rat Kupffer cells expressed the corresponding chemokine, macrophage inflammatory protein-1α. Recruited DC precursors phagocytosed latex or bacteria and some of them soon translocated to hepatic nodes and induced the immune response there. We conclude that after invasion of pathogens, Kupffer cells not only scavenge them but also recruit DCs/DC precursors via chemokine- and N-acetylgalactosamine-mediated interactions. The accelerated DC traffic and the presence of blood-lymph translocation would induce rapid and efficient immune responses and thus contribute to the local defense to antigens within liver tissues as well as systemic defense to blood-borne antigens.