Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2007, Article ID 39245, 6 pages
http://dx.doi.org/10.1155/2007/39245
Research Article

CRALBP is a Highly Prevalent Autoantigen for Human Autoimmune Uveitis

1Institute for Animal Physiology, Ludwig-Maximilians University, Veterinärstraße 13, Munich 80539, Germany
2Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
3Section of Immunobiology, Department of Ophthalmology, Ludwig-Maximilians University, Mathildenstraße 8, Munich 80336, Germany
4Institute of Human Genetics, GSF National-Research Center for Environment and Health, Ingolstaedter Landstraße 1, Neuherberg 85764, Germany
5Institute of Human Genetics, Technical University of Munich, Trogerstraße 32, Munich 81675, Germany

Received 18 June 2007; Accepted 20 August 2007

Academic Editor: Eiji Matsuura

Copyright © 2007 Cornelia A. Deeg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. A. Deeg, D. Pompetzki, A. J. Raith et al., “Identification and functional validation of novel autoantigens in equine uveitis,” Molecular & Cellular Proteomics, vol. 5, no. 8, pp. 1462–1470, 2006. View at Publisher · View at Google Scholar
  2. W. B. Wacker, L. A. Donoso, C. M. Kalsow, J. A. Yankeelov Jr., and D. T. Organisciak, “Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina,” Journal of Immunology, vol. 119, no. 6, pp. 1949–1958, 1977. View at Google Scholar
  3. R. R. Caspi, F. G. Roberge, C.-C. Chan et al., “A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens,” Journal of Immunology, vol. 140, no. 5, pp. 1490–1495, 1988. View at Google Scholar
  4. J. C. Saari and J. W. Crabb, “Focus on molecules: cellular retinaldehyde-binding protein (CRALBP),” Experimental Eye Research, vol. 81, no. 3, pp. 245–246, 2005. View at Publisher · View at Google Scholar
  5. M. Nawrot, K. West, J. Huang et al., “Cellular retinaldehyde-binding protein interacts with ERM-binding phosphoprotein 50 in retinal pigment epithelium,” Investigative Ophthalmology & Visual Science, vol. 45, no. 2, pp. 393–401, 2004. View at Publisher · View at Google Scholar
  6. D. A. Thompson and A. Gal, “Vitamin A metabolism in the retinal pigment epithelium: genes, mutations, and diseases,” Progress in Retinal and Eye Research, vol. 22, no. 5, pp. 683–703, 2003. View at Publisher · View at Google Scholar
  7. M. D. de Smet, G. Bitar, S. Mainigi, and R. B. Nussenblatt, “Human S-antigen determinant recognition in uveitis,” Investigative Ophthalmology & Visual Science, vol. 42, no. 13, pp. 3233–3238, 2001. View at Google Scholar
  8. C. A. Deeg, B. Kaspers, H. Gerhards, S. R. Thurau, B. Wollanke, and G. Wildner, “Immune responses to retinal autoantigens and peptides in equine recurrent uveitis,” Investigative Ophthalmology & Visual Science, vol. 42, no. 2, pp. 393–398, 2001. View at Google Scholar
  9. J. W. Crabb, A. Carlson, Y. Chen et al., “Structural and functional characterization of recombinant human cellular retinaldehyde-binding protein,” Protein Science, vol. 7, no. 3, pp. 746–757, 1998. View at Google Scholar
  10. J. Seissler and W. A. Scherbaum, “Are we ready to predict and prevent endocrine/organ specific autoimmune diseases?” Springer Seminars in Immunopathology, vol. 24, no. 3, pp. 273–295, 2002. View at Publisher · View at Google Scholar
  11. T. Okazaki and T. Honjo, “Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy,” Trends in Molecular Medicine, vol. 11, no. 7, pp. 322–326, 2005. View at Publisher · View at Google Scholar
  12. R. H. Scofield, “Autoantibodies as predictors of disease,” The Lancet, vol. 363, no. 9420, pp. 1544–1546, 2004. View at Publisher · View at Google Scholar
  13. N. R. Rose and C. Bona, “Defining criteria for autoimmune diseases (Witebsky's postulates revisited),” Immunology Today, vol. 14, no. 9, pp. 426–430, 1993. View at Publisher · View at Google Scholar
  14. S. M. Hauck, S. Suppmann, and M. Ueffing, “Proteomic profiling of primary retinal Müller glia cells reveals a shift in expression patterns upon adaptation to in vitro conditions,” Glia, vol. 44, no. 3, pp. 251–263, 2003. View at Publisher · View at Google Scholar
  15. T. M. Martin, J. R. Smith, and J. T. Rosenbaum, “Anterior uveitis: current concepts of pathogenesis and interactions with the spondyloarthropathies,” Current Opinion in Rheumatology, vol. 14, no. 4, pp. 337–341, 2002. View at Publisher · View at Google Scholar
  16. R. R. Caspi, F. G. Roberge, C. G. McCallister et al., “T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat,” Journal of Immunology, vol. 136, no. 3, pp. 928–933, 1986. View at Google Scholar
  17. C. E. Egwuagu, R. M. Mahdi, R. B. Nussenblatt, I. Gery, and R. R. Caspi, “Evidence for selective accumulation of V β 8+ T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens,” Journal of Immunology, vol. 151, no. 3, pp. 1627–1636, 1993. View at Google Scholar
  18. S. R. Thurau, M. Diedrichs-Möhring, H. Fricke, S. Arbogast, and G. Wildner, “Molecular mimicry as a therapeutic approach for an autoimmune disease: oral treatment of uveitis-patients with an MHC-peptide crossreactive with autoantigen—first results,” Immunology Letters, vol. 57, no. 1–3, pp. 193–201, 1997. View at Publisher · View at Google Scholar
  19. H. H. Hofstetter, O. S. Targoni, A. Y. Karulin, T. G. Forsthuber, M. Tary-Lehmann, and P. V. Lehmann, “Does the frequency and avidity spectrum of the neuroantigen-specific T cells in the blood mirror the autoimmune process in the central nervous system of mice undergoing experimental allergic encephalomyelitis?” Journal of Immunology, vol. 174, no. 8, pp. 4598–4605, 2005. View at Google Scholar
  20. E. Märker-Hermann, K.-H. Meyer zum Büschenfelde, and G. Wildner, “HLA-B27-derived peptides as autoantigens for T lymphocytes in ankylosing spondylitis,” Arthritis & Rheumatism, vol. 40, no. 11, pp. 2047–2054, 1997. View at Publisher · View at Google Scholar
  21. M. D. de Smet, M. Dayan, and R. B. Nussenblatt, “A novel method for the determination of T-cell proliferative responses in patients with uveitis,” Ocular Immunology & Inflammation, vol. 6, no. 3, pp. 173–178, 1998. View at Publisher · View at Google Scholar
  22. S. Hoppu, T. Härkönen, M. S. Ronkainen, H. K. Åkerblom, and M. Knip, “IA-2 antibody epitopes and isotypes during the prediabetic process in siblings of children with type 1 diabetes,” Journal of Autoimmunity, vol. 23, no. 4, pp. 361–370, 2004. View at Publisher · View at Google Scholar
  23. J. M. Barker, K. J. Barriga, L. Yu et al., “Prediction of autoantibody positivity and progression to type 1 diabetes: diabetes autoimmunity study in the young (DAISY),” Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 8, pp. 3896–3902, 2004. View at Publisher · View at Google Scholar
  24. J. M. LaGasse, M. S. Brantley, N. J. Leech et al., “Successful prospective prediction of type 1 diabetes in schoolchildren through multiple defined autoantibodies: an 8-year follow-up of the Washington state diabetes prediction study,” Diabetes Care, vol. 25, no. 3, pp. 505–511, 2002. View at Publisher · View at Google Scholar
  25. C. A. Deeg, B. Amann, A. J. Raith, and B. Kaspers, “Inter- and intramolecular epitope spreading in equine recurrent uveitis,” Investigative Ophthalmology & Visual Science, vol. 47, no. 2, pp. 652–656, 2006. View at Publisher · View at Google Scholar
  26. A. Wenzel, J. von Lintig, V. Oberhauser, N. Tanimoto, C. Grimm, and M. W. Seeliger, “RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice,” Investigative Ophthalmology & Visual Science, vol. 48, no. 2, pp. 534–542, 2007. View at Publisher · View at Google Scholar