Lack of Disease Specificity Limits the Usefulness of In Vitro Costimulation in HIV- and HCV-Infected Patients
Figure 1
Increased responses to NS3 protein in
HCV-infected patients only after in vitro costimulation with IL-7/IL-15 or
anti-CD28. PBMCs of 10 HCV-infected
patients were tested in IFN-γ ELISPOT assays for their recall responses to NS3
protein and Pepset 4 peptide pool in the absence (a) or presence of IL-7/IL-15
(b), IFN-α (c), anti-ICOS (d), or CD28 (e). For each individual, the mean spot count of duplicate wells is
shown. Horizontal bars indicate the
means of all individual responses to the respective antigens. P values are given for means that are
significantly different from baseline values in (a). Symbols in (a) also apply to (b)–(e).
