Review Article

The Fetal Allograft Revisited: Does the Study of an Ancient Invertebrate Species Shed Light on the Role of Natural Killer Cells at the Maternal-Fetal Interface?

Figure 1

Botryllus schlosseri colony formation. The B. schlosseri individual is called a zooid. It attaches to the substrate that it will grow on by one end. Its free end has two openings or siphons. The zooid reproduces asexually and groups of 3–12 zooids will group together to form a cluster or system, with the free end of each zooid dumping into a central chamber. Clusters, in turn, join to form the B. schlosseri colony. All clusters in a colony are housed in a common tunic and share a common vasculature. Vessels in a colony terminate in peripheral ampullae that, while covered in the tunic, present sites of colony-to-colony interactions.
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