A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry

Figure 4

Inhibition of anti-dsDNA antibodies binding to dsDNA antigen by purified bacterial antigen. ELISA plates were coated with dsDNA (50 𝜇g/mL). Lane 1, 2, and 3 are three different patients anti-dsDNA antibodies. The light column shows the patient purified anti-dsDNA antibodies (1.25 𝜇g/100 uL) binding to dsDNA antigen, and dark column shows the patient purified anti-dsDNA antibodies (1.25 𝜇g/100 uL) mixed with purified bacterial antigen(10 𝜇g/100 uL). The data were expressed as the mean ± SD.