Research Article

Aflatoxin-Related Immune Dysfunction in Health and in Human Immunodeficiency Virus Disease

Table 2

Summary of the immune indices in which significant differences ( value) were identified by intra- and intergroup comparisons among high and low aflatoxin B1 albumin adduct (AF-ALB) and HIV positive and HIV negative participants.

Cell subset (percentage)Intergroup comparisonIntragroup comparison
High AF-ALBLow AF-ALBHIV positiveHIV negative
HIV positive versus negativeHIV positive versus negativeHigh versus Low AF-ALBHigh versus Low AF-ALB

Lymphocytes (count) ↓ 0.003 ↓ 0.045
CD4+ cells ↓ 0.000 ↓ 0.000
CD4+ cells (count) ↓ 0.000 ↓ 0.000
CD4+CD28+ ↓ 0.000 ↓ 0.000
CD45RA+CD62L+CD4+ ↓ 0.029
CD45RO+CD45RA-CD4+
CD4+HLA-DR+CD38+ ↑ 0.000 ↑ 0.000
CD4+CD25+ ↓ 0.001 ↓ 0.016
CD4+CD25+CD45RO+ ↓ 0.000 ↓ 0.061 ↓ 0.009
CD4+CD25-CD45RO- ↑ 0.000 ↑ 0.000
CD4+CD25-CD45RO+ ↑ 0.000 ↑ 0.000
CD8 ↑ 0.000 ↑ 0.000
CD8+CD28+ ↓ 0.000 ↓ 0.000 ↑ 0.022
CD45RA+CD62L+CD8+ ↓ 0.017 ↓ 0.003
CD45RO+CD45RA-CD8+ ↑ 0.006 ↑ 0.002
CD8+HLA-DR+CD38+ ↑ 0.000 ↑ 0.000
CD8+CD27-CD45RA+ ↑ 0.038
CD8+CD27+CD45RA+ ↓ 0.03
CD8+CD27-CD45RA-
CD8+Perforin+ ↑ 0.000 ↑ 0.000 ↓ 0.012 ↓ 0.008
CD8+Granzyme A+ ↑ 0.000 ↑ 0.003
CD8+Granzyme A+Perforin+ ↑ 0.000 ↑ 0.002 ↓ 0.010
CD3-CD19+ ↓ 0.03
CD19+CD69+ ↓ 0.000 ↓ 0.027
CD3+
CD3+CD69+ ↓ 0.024
CD3-CD56+
CD3-CD16+CD56+ ↑ 0.052
CD3+CD56+Perforin