Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers

Table 1

Clinical and demographic data of study population.

Variable	COPD	Healthy
	patients	smokers
	(𝑛=134)	(𝑛=106)
Sex
Male (𝑛, %)	133 (99.25)	102 (96.23)
Female (𝑛, %)	1 (0.75)	4 (3.77)
Age (years ± STDEV)	69.4 ± 8.9	63 ± 9.6
BMI (Kg/m^2) (mean ± STDEV)	27.9 ± 5.8	27.7 ± 5.8
<30 Kg/m^2 (𝑛, %)	96 (71.6)	74 (69.8)
≥30 Kg/m^2 (𝑛, %)	38 (28.3)	32 (30.1)
Smoking status
Current Smokers (𝑛, %)	53 (39.5)	74 (69.8)
Ex Smokers (𝑛, %)	81 (60.4)	32 (30.1)
Pys (mean ± STDEV)	70.9 ± 37.8	54.8 ± 23.3
COPD stage
Mild (FEV1≥ 80%) (𝑛, %)	6 (4.4)
Moderate (FEV1: 50%–79%) (𝑛, %)	74 (55.2)
Severe (FEV1: 30%–49%) (𝑛, %)	40 (29.8)
Very severe (FEV1< 30%) (𝑛, %)	14 (10.4)
Frequency of exacerbations
Frequent exacerbators (𝑛, %)	34 (27.6)
Nonfrequent exacerbators (𝑛, %)	89 (72.3)

Abbreviations: COPD, chronic obstructive pulmonary disease; BMI, body mass index; Pys, pack years.