Journal of Immunology Research / 2009 / Article / Tab 2

Research Article

Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers

Table 2

Distribution of the TLR SNPs in smokers with and without COPD.

VariableCOPD patients ( 𝑛 = 1 3 4 ) Controls ( 𝑛 = 1 0 6 ) 𝑃 OR (95% CI)

TLR2-R753QgenotypeG/G (wt)129103.311
(2258G/A)G/A (het)53
A/A (hom)00
alleles ( 𝑛 , %)G263 (98.1)487 (96.7).3170.54 (0.16–1.77)
A5 (1.9)3 (3.3)
TLR4-D299GgenotypeA/A (wt)11397.095
(896A/G)A/G (het)219
G/G (hom)00
alleles ( 𝑛 , %)A247 (92.2)203 (95.8).1002.0 (0.87–4.57)
G21 (7.8)9 (4.2)
TLR4-T399IgenotypeC/C (wt)11298.039
(1196C/T)C/T (het)228
T/T (hom)00
alleles ( 𝑛 , %)C246 (95.7)204 (96.3).0442.4 (1.02–5.64)
A22 (8.2)8 (3.7)
Haplotypes ( 𝑛 , % )
TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299D-399T110 (82.1)90 (84.9).081
TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299G-399I20 (14.9)8 (7.5)
TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299G-399T0 (0)1 (0.9)
TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299D-399T1 (0.7)0 (0)
TLR2-753R/TLR4-299D-399T - TLR2-753Q/TLR4-299D-399I2 (1.5)7 (6.6)
TLR2-753R/TLR4-299D-399T - TLR2-753Q/TLR4-299G-399I1 (0.7)0 (0)

Abbreviations: COPD, chronic obstructive pulmonary disease; CI, confidence intervals; wt, wild-type; het, heterozygous; hom, homozygous.

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