Research Article
Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers
Table 2
Distribution of the TLR SNPs in smokers with and without COPD.
| | Variable | COPD patients | Controls | | OR (95% CI) |
| | TLR2-R753Q | genotype | G/G (wt) | 129 | 103 | .311 | | | (2258G/A) | | G/A (het) | 5 | 3 | | | | | A/A (hom) | 0 | 0 | | | | alleles (, %) | G | 263 (98.1) | 487 (96.7) | .317 | 0.54 (0.16–1.77) | | | A | 5 (1.9) | 3 (3.3) | | | | TLR4-D299G | genotype | A/A (wt) | 113 | 97 | .095 | | | (896A/G) | | A/G (het) | 21 | 9 | | | | | G/G (hom) | 0 | 0 | | | | alleles (, %) | A | 247 (92.2) | 203 (95.8) | .100 | 2.0 (0.87–4.57) | | | G | 21 (7.8) | 9 (4.2) | | | | TLR4-T399I | genotype | C/C (wt) | 112 | 98 | .039 | | | (1196C/T) | | C/T (het) | 22 | 8 | | | | | T/T (hom) | 0 | 0 | | | | alleles (, %) | C | 246 (95.7) | 204 (96.3) | .044 | 2.4 (1.02–5.64) | | | A | 22 (8.2) | 8 (3.7) | | | | Haplotypes | | | | | | TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299D-399T | 110 (82.1) | 90 (84.9) | .081 | | | TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299G-399I | 20 (14.9) | 8 (7.5) | | | | TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299G-399T | 0 (0) | 1 (0.9) | | | | TLR2-753R/TLR4-299D-399T - TLR2-753R/TLR4-299D-399T | 1 (0.7) | 0 (0) | | | | TLR2-753R/TLR4-299D-399T - TLR2-753Q/TLR4-299D-399I | 2 (1.5) | 7 (6.6) | | | | TLR2-753R/TLR4-299D-399T - TLR2-753Q/TLR4-299G-399I | 1 (0.7) | 0 (0) | | |
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Abbreviations: COPD, chronic obstructive pulmonary disease; CI, confidence intervals; wt, wild-type; het, heterozygous; hom, homozygous.
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