Different Activity of the Biological Axis VEGF-Flt-1 (fms-Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveolar Lavage Study

Table 4

mRNA expression of VEGF, FLT-1 and angiogenetic chemokines in healthy subjects (Controls), Sarcoidosis (SARC) and IPF patients. Values are expressed as mean ± SD.

Variables	Controls	IPF	SARC	P1 value	P2 value	P3 value
VEGF	2.82 ± 3.6	18.3 ± 14.9	2.99 ± 1.43	NS	.03	.03
Flt-1	134.6 ± 23.5	154.1 ± 33.5	204 ± 52	NS	NS	NS
CXCR2	0.001 ±0.002	0.08 ± 0.25	0.0004 ± 0.001	NS	NS	NS
CXCR3	0.03 ± 0.002	0.12 ± 0.39	0.0001 ± 0.0004	NS	NS	NS
CXCR4	0.86 ± 0.64	174.3±543.6	153.9 ± 129.3	NS	.03	NS
CXCL12𝛼	92.2 ± 132.17	168.5±576.7	1525.2 ± 2224.7	NS	NS	.02
CXCL12𝛽	223.8 ± 176.6	142.4 ± 563.7	822.4 ± 1423.0	NS	NS	NS

NS: Non significant, P <   .050 is considered statistically significant,
P1: P value between controls and IPF,
P2: P value between controls and Sarcoidosis,
P3: P value between IPF and Sarcoidosis.