The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRL/lpr Mice

Table 1

Effects of UVA1 irradiation on the development of spontaneous LE-like skin lesions in MRL/lpr mice.

Mice		Skin lesions		Total
	−	+	++
Nonirradiated	12	4 (18.2)	6 (27.3)	22
UVA1	31	5 (13.9)	0	36#
5 J/cm^2	16	2 (11.1)	0	18$
10 J/cm^2	15	3 (16.7)	0	18

(++): mice with macroscopic skin lesions;
(+): mice with only histological change in the skin;
(−): mice without skin lesions;
Regarding the frequency of spontaneous LE-like skin lesions in MRL/lpr mice, there was a significant difference between the non-irradiated and all UVA1-irradiated groups (#, 𝑝<0.05), and between the non-irradiated and UVA1-irradiated (only 5 J/cm²) group ($, 𝑝<0.05). UVA1 irradiation significantly protected mice against the development of LE-like skin lesions.