Review Article
Mizoribine: A New Approach in the Treatment of Renal Disease
Table 5
Adverse reactions to MZB.
| | Renal Transplantation | Lupus Nephritis | Rheumatoid Arthritis | Nephrotic Syndrome | Total |
| Number of surveyed cases | 916 | 275 | 3478 | 240 | 4909 | Number of adverse reaction cases | 186 | 33 | 462 | 38 | 719 | Number of adverse reaction episodes | 229 | 47 | 658 | 49 | 983 | Incidence of adverse reaction cases | 20.31% | 12.00% | 13.28% | 15.83% | 14.65% |
| Incidence of Adverse Reactions (%) |
| Blood | | | | | | Leukopenia | 6.99 | 2.55 | 0.20 | 0.83 | 1.63 | Thrombocytopenia | 0.98 | 0.73 | 0.14 | | 0.33 | Anaemia | 0.44 | 0.36 | 0.72 | 0.42 | 0.63 | Infection | | | | | | Pneumonia | 0.55 | | 0.03 | 0.42 | 0.14 | Mycosis pulmonary | 0.55 | | | | 0.10 | Herpes zoster | 0.76 | 1.45 | 0.17 | | 0.35 | Other viral infection | 0.76 | | 0.03 | | 0.16 | Liver | | | | | | Hepatic function abnormal | 4.15 | 1.09 | 1.18 | 2.29 | 1.81 | Hypersensitivity | | | | | | Rash | | 1.09 | 1.64 | 2.08 | 1.32 | Prurigo | | | 1.09 | | 0.77 | Metabolic | | | | | | Uric acid increased | 1.64 | 1.45 | 0.43 | 2.50 | 0.81 | Gastrointestinal | | | | | | Celialgia | | 0.36 | 2.21 | 1.67 | 1.67 | Anorexia | 0.98 | 1.09 | 1.12 | 0.83 | 1.08 | Vomiting | 0.55 | 1.09 | 1.18 | 0.42 | 1.02 | Nausea | 0.11 | 1.09 | 0.23 | | 0.24 | Diarrhea | 0.22 | 0.73 | 0.63 | 0.42 | 0.55 | Stomatitis | 0.76 | 0.73 | 0.66 | 0.42 | 0.67 | Skin | | | | | | Epilation | 1.09 | 1.09 | 0.29 | 1.67 | 0.55 |
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Note. Listed adverse reactions occurred in 0.5% of cases of greater for at least one indication of MZR.
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