(i) Lower proliferation potential for B-lymphocytes of hemodialysis patients. (ii) (1–34) and (1–84) PTH produced dose-dependant inhibition of proliferation. (iii) (1–84) inhibitory effect was more than (1–34).
Bovine (1–84) PTH, bovine (1–34) PTH. PTH was added at the beginning and at day 2.
Stimulation with S. aureus cowan strain I
(i) (1–84) and (1–34) PTH inhibited immunoglobulin production. (ii) At the lower dose of (1–84) PTH had no inhibition of B lymphocytes of ESRD patients. (iii) Inactivated (1–84) had no inhibitory effect. (iv) The inhibition was only observed when PTH was added at the beginning of the culture.
Human B-cell lines (CBL3, SKW6.4, CESS). Incubated for 5 days
Human (1–84) PTH
Stimulation with S. aureus cowan strain I
(i) PTH directly inhibits Ig production by B lymphocytes. (ii) PTH did not affect B-cell growth (iii) IL-4 reduced the inhibitory effect of PTH on Ig production.